Amyloid beta precursor protein (APP) and prion protein (PrP) are cell membrane elements implicated in neurodegenerative diseases. Both proteins undergo endoproteolysis. Evidence is adduced from the literature hinting that the process in the two proteins could be related, their functions may overlap ...
The cellular prion protein (PrPC) is a cell surface protein expressed in a variety of different organs and tissues with high expression levels in the central and peripheral nervous systems [1]. It is mainly known for its infamous role in prion diseases, where its misfolding and aggregation cau...
Transgenic mice expressing human mutated superoxide dismutase 1 (SOD1) linked to familial forms of amyotrophic lateral sclerosis are frequently used as a disease model. We used the SOD1G93A mouse in a cross-breeding strategy to study the function of physiological prion protein (Prp). SOD1G93A...
Prion protein is necessary for normal synaptic function translationally modified form of a host-encoded glycoprotein (PrP c ), designated PrP Sc (ref. 1); the normal cellular function of PrP c is, however... J Collinge,MA Whittington,KCL Sidle,... - 《Nature》 被引量: 1433发表: 1994年...
Prion proteinWe evaluated the role of prion protein in mouse primary microglia.There were no differences in the activation and function of cells regardless PrPC expression.We suggest a cautionary approach when testing PrPC actions in cell lines alone.doi:10.1016/j.jneuroim.2015.07.002...
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable 3D structure. These regions are structurally heterogeneous, ubiquitous and found across all kingdoms of life. Despite the absence of a defined 3D structure, disordered regions are ess...
Intrinsically disordered protein regions exist in a collection of dynamic interconverting conformations that lack a stable 3D structure. These regions are structurally heterogeneous, ubiquitous and found across all kingdoms of life. Despite the absence of a defined 3D structure, disordered regions are ess...
Prion protein is necessary for normal synaptic function. Demonstrates that a post-transitionally modified form of a host-encoded glycoprotein in a prion is required for normal synaptic function. Electrophysiologi... Collinge,John,Whittington,... - 《Nature》 被引量: 940发表: 1994年 Prion Protein...
1.2.4 Application of CW-EPR to Protein (Clock Protein, Amyloid Proteins, and HP1) 21 1.2.4.1 Clock Proteins 22 1.2.4.2 Amyloid Proteins (Aβ Peptide, β2-microglobulin, α-synuclein, Tau, and Prion) 23 1.2.4.3 Heterochromatin Protein 1 (HP1) 26 ...
Here, we identified a GPI-anchored protein called Undicht required for septate junction formation. Clonal analysis and rescue experiments show that Undicht acts in a non-cell-autonomous manner. It can be released from the plasma membrane by the proteolytic activity of two related ADAM10-like ...