Understanding the structure-function relationships of both healthy and disease-associated prion proteins enables a deeper understanding of the mechanisms of prion-induced neurotoxicity. Furthermore, we describe how insights into prion evolution have begun to shed light on their ancient origins and ...
别名:蛋白质:结构、功能与生物信息学;Proteins, structure, function, and bioinformatics;PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 国际标准连续出版物号:ISSN0887-3585 创刊时间:1987年 曾用名:PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 热门主题:
Human cells express more than 20,000 genes, which direct synthesis of a comparable number of proteins by the ribosome. Intracellular constituents dynamically preserved as proteins are continuously synthesized and degraded in cells. Newly synthesized proteins might misfold into dysfunctional structures that ...
Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders. Several neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's and prion diseases, are characterized pathognomonically by the presenc... F Rahimi,A Shanmugam,G Bitan ...
The growing list of known amyloid related activities (Table 1) shows that the formation of amyloids may result both in a loss of function of the polypeptide, as described for the yeast prions (Osherovich and Weissman, 2002, True and Lindquist, 2000), or in a gain of function, as in ...
The members of a protein family will typically have similar sequences and/or structures and related functions. Orthologues Evolutionarily related genes in different species. The proteins encoded by orthologous genes are typically responsible for the same function in the respective organisms. Paralogues ...
The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the sub-ångström-resolution structure of a protofibril formed by a wild-type segm
Ultrasounds are used in many industrial, medical and research applications. Properties and function of proteins are strongly influenced by the interaction with the ultrasonic waves and their bioactivity can be lost because of alteration of protein structure. Surprisingly, to the best of our knowledge ...
Tuite, M.F., Marchante, R., Kushnirov, V. (2011). Fungal Prions: Structure, Function and Propagation. In: Tatzelt, J. (eds) Prion Proteins. Topics in Current Chemistry, vol 305. Springer, Berlin, Heidelberg. https://doi.org/10.1007/128_2011_172 ...
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