Around 15% of all prion diseases arise due to dominantly inherited mutations in the PRNP gene, which encodes the ubiquitously expressed, highly conserved prion protein, PrPC. The normal function of PrP remains elusive, however, and we have learnt relatively little about this from PrP knockout ...
The Prion Protein in Normal Cells and Disease Studies on the Cellular Processing of Bovine PrP C andKlingeborn, MikaelKlingeborn M. 2006. The Prion protein in Normal cells and Disease: Studies on the Cellular Processing of Bovine PrPC and molecular Charachterization of the Nor98 Prion....
We compared the conformation between wild-type human prion protein (rPrPC) with either a valine or methionine at position 129, using a panel of monoclonal antibodies that are specific for epitopes along the entire protein. We found that rPrPC(129M) has a more exposed helix 1 region compared...
Pax-3 was found upstream of the following transcripts: prion protein (prnp), cathepsin L (ctsl), stromal cell derived factor receptor 1 (sdfr1) [31], thrombospondin, type I domain containing 6 (thsd6), and uroplakin 1b (upk1b).Prnpseems to be involved in cell-to-cell interaction an...
14. Vella LJ, Greenwood DL, Cappai R, Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid: Vet Immunol Immunopathol, 2008; 124(3–4); 385-93 15. Wubbolts R, Leckie RS, Veenhuizen PT, Proteomic and biochemical analyses of human B cell-derived exosomes. Potentia...
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Such comparative analyses of sequence conservation and structural dynamics lead to a better understanding of the interplay between evolution and function [1,40,43,46,47]. Integration of network models with sequence evolutionary analysis emerges as a useful tool for elucidating mechanisms of action [48...
Around 15% of all prion diseases arise due to dominantly inherited mutations in the PRNP gene, which encodes the ubiquitously expressed, highly conserved prion protein, PrPC. The normal function of PrP remains elusive, however, and we have learnt relatively little about this from PrP knockout ...
(2014) Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiolog- ical stress. Microbiol. Immunol. 58, 361-374.Onodera T, Sakudo A et al (2014) Review of studies that have used knockout mice to assess normal function...
Cell biology, genetic and putative function of the normal prion proteindoi:10.1201/9781420040128.CH4C. Soto