In terms of understanding the development of autoimmunity to CNS antigen as seen in multiple sclerosis (MS), two prevailing hypotheses have emerged: that primary aberrant activation of CNS-specific peripheral immune cells causes these cells to enter the CNS where they initiate injury (the "outside...
Dendritic cells (DC) play a key role in determining the appropriate immune response to invading pathogens and tolerance to self antigens. Here I review the evidence that dendritic cell functions may be tuned by the sympathetic nervous system via the local release of norepinephrine. In the presence...
CD40 has emerged as a key signaling pathway for the function of B cells, monocytes, and dendritic cells (DC) in the immune system, and plays a major role in inflammatory pathways of nonhemopoletic cells. CD40 is expressed by monocytes and DC and is up-regulated when DC migrate from the...
While dendritic cells play a central role in the activation of naive T cells and associated immunological responses, they also promote immune tolerance towards self-antigens thus preventing the occurrence of autoimmune disease. In human beings and other animals, a variety of dendritic cells have been...
cells. Using flow cytometry, we detected significantly less CD4+and CD8+T cell proliferation in co-cultures that contained LNG-treated DCs (Fig. 2a–c). Of note, all but the lowest selected LNG concentration significantly inhibited this proliferation. Conversely, the stimulation of T cell-only ...
INTRODUCTION Dendritic cells (DCs) have a pivotal role in immune homeo- stasis, marshaling immunity against pathogens, while main- taining tolerance to commensals. The nasal associated lymphoid tissue (NALT) serves as a site for the induction of nasal,1,2 pharyngeal,3 respiratory,4 oral,2 ...
In addition, MSC interacts with immune system, suppressing T cell, B cell and NK cell function and dendritic cell activities. MSC migrates to injured tissue to promote the survival of damaged cells and induces peripheral immune tolerance. The role of MSC in reducing the incidence and severity ...
Cells of the innate and adaptive immune systems play a critical role in the host response to sepsis. Moreover, their accessibility for sampling and their capacity to respond dynamically to an acute threat increases the possibility that leukocytes might serve as a measure of a systemic state of ...
- International Conference on Power System Technology 被引量: 32发表: 2000年 Relationship between expression of toll-like receptors 2/4 in dendritic cells and chronic hepatitis B virus infection toll-like receptor 2/4 (TLR2/4) in peripheral blood dendritic cells (DCs), to find out the ...
Tumor necrosis factor (TNF)-α-induced protein 8-like 2 (TIPE2) is a newly discovered negative immunoregulatory protein that is involved in various cellular immune responses to infections. However, the underlying mechanism by which TIPE2 affects the immune function of dendritic cells (DCs) is not...