Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals Dendritic cells are antigen-presenting cells (APC), which are crucial for the initiation of an immune response. In spite of the well known decline of immun... MM Steger,C Maczek,...
Choe, "Beraprost enhances the APC function of B cells by upregulating CD86 expression levels," Journal of Immunology, vol. 186, no. 7, pp. 3866-3873, 2011.Kim J, Park CS, Park CH, Jeoung DI, Kim YM, Choe J: Beraprost enhances the APC function of B cells by upregulat- ing CD86 ...
This increased APC activity was due to the non-LC T6-DR+HLe1+ APC population and not to DR+ keratinocytes. These results demonstrate that involved psoriatic epidermal cells contain both an increased number and function of antigen-presenting cells. The pathogenetic mechanisms in psoriasis may be ...
Li, W., et al., Apc regulates the function of hematopoietic stem cells largely through beta- catenin-dependent mechanisms. Blood, 2013. 121(20): p. 4063-72.Li, W., Hou, Y., Ming, M., Yu, L., Seba, A., and Qian, Z. (2013). Apc regulates the function of hematopoietic stem ...
In the present study, we have identified a cloned macrophage cell line (FLJ2) with inducible APC function. The unactivated FLJ2 line could not induce T-cell proliferation. FLJ2 could present alloantigen, and stimulate proliferation of either a T-cell clone or normal resting T cells following ...
董晨团队2018年在Immunity发表题为“Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infifiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells”的论文,重点分享膜分子蛋白在肿瘤免疫研究中的思路和方法。 肝细胞癌患者对抗PD-1治疗的总体反应率仅为 20%,其他类型肿瘤也只有...
Here, we establish that IFN-β inhibits mouse IFN-γ+ Th1 cell function in the absence of APCs. CD4+ T cells express the type I interferon receptor, and IFN-β can suppress Th1 cell proliferation under APC-free stimulation conditions. IFN-β-treated myelin antigen-specific Th1 cells are ...
Adhesive interactions slow down the movement apart of the APC and T cell. (5) The Immunological Synapse. –The area of contact between APC and T cell. –The synapse is required for sustained intracellular signaling, lasting until the two cells split apart after 8 hours of contact. ...
A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in the... Loss-of-function mutations of the c- kit receptor tyrosine kinase (KIT) result in depletion of mast cells and interstitial cells of...
Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest. 2010;120(1):254–65. Article CAS PubMed Google Scholar Van Linthout S, Miteva K, Tschope C. Crosstalk between fibroblasts and inflammatory cells. Cardiovasc Res. 2014;102(...