TUMOR-SUPPRESSOR GENECYCLE PROGRESSIONSELF-RENEWALS-PHASEDNA METHYLTRANSFERASEWNT/BETA-CATENINPROGENITOR CELLSPROTEINWNTEmerging evidence suggests that adenomatous polyposis coli(Apc) plays a critical role in the maintenance of hematopoietic stem/progenitor cells (HSCs/HPCs). The molecular pathways responsible...
Polakis P (1995): Mutations in the APC gene and their implications for protein structure and function. Curr Opin Gen Dev 566-71.Polakis P. Mutations in the APC gene and their implica- tion for protein structure and function. Curr Opin Genet Dev. 1995; 5: 66....
The use of models to study is proving particularly powerful in dissecting the mechanisms underlying disease initiation and progression. However, the majority of these models have been somewhat limited in studying the very early effects of loss of gene function, as relies upon either constitutive loss...
Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair. J Immunol. 2003;171(7):3655–67. Article CAS PubMed Google Scholar Yu Q, Horak K, Larson DF. Role of T lymphocytes in hypertension-induced ...
Interleukin-4 (IL-4) induces tyrosine phosphorylation of the latent transcription factor Stat6, which mediates the transcriptional responses of IL-4. The t... Gingras,Simard,Groner,... - 《Nucleic Acids Research》 被引量: 233发表: 1999年 The APC/C and CBP/p300 cooperate to regulate transcr...
NO is generated by antigen-presenting cells (APC) during the process of antigen presentation to T cells. In mouse models, activation of the inducible NO... RCVD Veen - 《International Immunopharmacology》 被引量: 304发表: 2001年 Disregulated expression of the Th2 cytokine gene in patients with...
generation and the evolution of cancer cells. Here, we first describe the molecular mechanisms underlying the recruitment and function of PcG proteins in gene regulation during normal development. We then review the involvement of Polycomb complexes in cancer, highlighting PcG-dependent disturbances of ...
The N-terminal region of ApCPEB, unique to the neuronal isoform, is responsible for the amyloid-like properties of the molecule. Like yeast prions that propagate as an amyloid, it has a Gln and Asn content of 48% and lacks predictable secondary structure. Because the mouse homolog has only...
Chromosome segregation is initiated by cohesin degradation, which is driven by anaphase-promoting complex/cyclosome (APC/C). Chromosome cohesin is removed by activated separase, with the degradation of securin and cyclinB1. Dynamin-related protein 1 (DRP
The T cell stimulatory capacity of NOD DC was suppressed by gene transfer of a modified form of IkappaBalpha, indicating a direct role for NF-kappaB in this process. Furthermore, neutralization of IL-12(p70) to block autocrine-mediated activation of DC also significantly reduced the capacity ...