Consistently, we found that IFNa-induced Epromoters have the ability to specifically and efficiently recruit the interferon-response transcription factors. In fact, within a typical cluster of IFNa-response genes, the interferon response factors are found to exclusively bind to the Epromoter, which ...
George AA, Sharma M, Singh BN, Sahoo NC, Rao KV (2006) Transcription regulation from a TATA and INR-less promoter: spatial segregation of promoter function . EMBO J 25 : 811–821A.A. George, M. Sharma, B.N. Singh, N.C. Sahoo, K.V. Rao, Transcription regulation from a TATA and...
We identify the signal in DNA that induces early pausing to be a version of the σ 70 10 promoter consensus, and we show that σ 70 is both necessary for pausing and present in the paused transcription complex. Regions 2 and 3 of σ 70 suffice to induce pausing. Since pausing is ...
The promoter region of NFL1 gene in tobacco was cloned by a novel PCR method,fused with the report gene GUS and transformed tobacco plants.The expression of GUS in the shoot apex of transgenic seedlings was detected.关键词: tobacco NFL gene promoter 被...
INSM1 is highly expressed in tumors of neuroendocrine origin. Hence, its promoter could serve as a tumor-specific promoter that drives a specific targeted cancer gene therapy for the treatment of neuroendocrine tumors. Taken together, all of these features of INSM1 strongly support its role as ...
Initiation of in vitro mRNA synthesis from the wild-type lac promoter. An in vitro transcription system, dependent on catabolite gene activator protein (CAP), utilizing a 200 base-pair restriction fragment, has been used to sh... J,Majors - 《Proceedings of the National Academy of Sciences of...
Also, mutant human p53 alleles, unlike the wild–type p53 protein, could also enhance the expression of a test gene regulated by the multi–drug resistance enhancer–promoter element. These data demonstrate a gain of function associated with p53 mutations in addition to the loss of function ...
Epigenetic mechanisms control various functions throughout the body, from cell fate determination in development to immune responses and inflammation. Neuroinflammation is one of the prime contributors to the initiation and progression of neurodegeneration in a variety of diseases, including Alzheimer's and...
(QTL),tin1, which encodes a C2H2-zinc-finger transcription factor that acts independently oftb1. In sweet maize, a splice-site variant from G/GT to C/GT leads to intron retention, which enhancestin1transcript levels and consequently increases tiller number. Comparative genomics analysis and DNA...
Alternative splicing affects more than 95% of multi-exon genes in the human genome. These changes affect the proteome in a myriad of ways. Here, we review our understanding of the breadth of these changes from their effect on protein structure to their influence on interactions. These changes ...