Systems Biology develops computational models in order to understand biological phenomena. The increasing number and complexity of such “bio-models” necessitate computer support for the overall modelling task. Computer-aided modelling has to be based on a formal semantic description of bio-models. But...
Understanding the evolutionary forces related to climate changes that have been shaped genetic variation within species has long been a fundamental pursuit in biology. In this study, we generated whole-genome sequence (WGS) data from 65 cross-bred and 45 Mongolian cattle. Together with 62 whole-ge...
Pancreatic β cells differentiated from stem cells provide promise for cell replacement therapy of diabetes. Human pluripotent stem cells could be differentiated into definitive endoderm, followed by pancreatic progenitors, and then subjected to endocrin
These structures typically form in response to pathogens, tissue damage, and necrosis, but this defense response can also be triggered by different genetic perturbations [46, 48,49,50]. Irrespective of the trigger, melanotic masses often form in the larval hemolymph and can be readily observed ...
The gut microbiota of the giant panda (Ailuropoda melanoleuca), a global symbol of conservation, are believed to be involved in the host’s dietary switch to a fibrous bamboo diet. However, their exact roles are still largely unknown. In this study, we f
As in many neurodegenerative diseases, AD is one in which polypeptides aggregate to form amyloid deposits. In AD, the aggregates of a protein called, amyloid-β (Aβ) peptide are strongly believed to be the cause for neuronal death and cognitive decline [1]. Primarily two forms of Aβ, ...
Genetic kinship of ancient individuals can provide insights into their culture and social hierarchy, and is relevant for downstream genetic analyses. However, estimating relatedness from ancient DNA is difficult due to low-coverage, ascertainment bias, o
Sea snakes underwent a complete transition from land to sea within the last ~ 15 million years, yet they remain a conspicuous gap in molecular studies of marine adaptation in vertebrates. Here, we generate four new annotated sea snake genomes, thre
Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of complex tissues at single-cell levels, can identify differential gene expression and epigenetic factors caused by mutations in unicellular genomes, as well as new cell-specific markers and cell types. scRNA-seq plays...
Are there other attachment mechanisms active in the toe pads and how do these mechanisms interact? Several questions concerning the functional morphology of the attachment apparatus also remain open. Can the smooth soft toe pads of tree frogs conform closely to rough substrates to form a large area...