MAF amplification increases the risk of breast cancer (BCa) metastasis through mechanisms that are still poorly understood yet have important clinical implications. Oestrogen-receptor-positive (ER+) BCa requires oestrogen for both growth and metastasis, albeit by ill-known mechanisms. Here we integrate...
Notably, combined treatment significantly downregulates a large set of genes associated with cell cycle progression. A full list of top GO terms is presented in Extended Data Fig. 9a. c, Heat map visualizing gene expression (log2-transformed TPM) associated with regulation of mitotic cell division...
c Compositional similarities between the nasal samples in terms of gain or loss of VJ combinations of IGK locus are measured across paired samples from the same group (Asthma, Controls) and paired samples from different groups (Asthma vs Controls) using Sørensen–Dice index. Lower level of sim...
If the proteotoxic crisis hypothesis is correct, it should be possible to identify cancer types and treatment regimes for which there is a favorable therapeutic index for killing tumor cells with mutation-riddled genomes while sparing normal cells. One place to start looking is in cancers that orig...
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The ...
Therefor, carbon atoms con form covalent bonds with up to four other atoms, including other carbon atoms. The prefix Mono- means "one," and the prefix Poly- means "many." How are these means related to the terms monomer and polymer? When monomers are linked, they form molecules called ...
(Rodríguez et al.1993; Tan and Yasin2001a). Starting with settlement and metamorphosis, locomotive activity declines with age, reflecting both anatomical constraints, in terms of byssus atrophy and shell weight-to-body mass ratio (Heslinga1989), as well as ecological needs—where more energy ...
The cells that remain unstained or insignificantly stained for both annexin and PI are live cells. Since you now know why cell biologists rely on this technique to study cell death, why don’t we review some of its applications. Using this procedure, scientists can follow which intracellular ...
the main anatomical characteristics of tracts obtained from six dead females (O. bezoarticus arerunguaensis). Three of them were prepubertal; the other three were adults that died during the spring at the ECFA, Uruguay. Anatomical terms are used according to the Nomina Anatomica Veterinaria [24...
Cancer-associated mutations that perturb cell cycle control allow continuous cell division chiefly by compromising the ability of cells to exit the cell cycle. Continuous rounds of division, however, create increased reliance on other cell cycle control mechanisms to prevent catastrophic levels of damage...