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The most enthusiastic proponent of this approach, the British biologist and logician Joseph Woodger (1894–1981), attempted to formalize the principles of biology—to derive them by deduction from a limited number of basic axioms and primitive terms—using the logical apparatus of the Principia ...
Starting with the quality controlled, normalized dataset, we initially determined probes that could be matched with exonic regions of the rat genome (or with a homologous human or mouse sequence). There are 14,622 unique rat RefSeq DNA IDs specified by the UCSC Genome Browser. Of these, 8,...
are mainly sourced from the natural environment or the GITs of animals. Therefore, we observed that anthropogenic genomes have been incorporated into both environmental and gastrointestinal clades (Fig.2A). We also found that the origin of the taxa did not always align with the clades to which ...
Comprehensive analysis of microRNAs modulated by histone deacetylase inhibitors identifies microRNA-7-5p with anti-myeloma effect Masahiro Yamada Sho Ikeda Naoto Takahashi International Journal of Hematology(2024) Amino acid metabolism in immune cells: essential regulators of the effector functions, and prom...
PubMed/MEDLINE searches were performed using the terms “osteoarthritis”, “cartilage”, “subchondral bone”, “synovium”, “synovitis”, and “ageing”. Biomechanical, genetic, genomic, epigenomic, biomarker, clinical, imaging, and tissue engineering studies were excluded since they are covered by...
vocabularies. Typically, between 50 and 80 % of the transcripts reconstructed from RNA-seq data can be annotated with functional terms in this way. However, RNA-seq data also reveal that an important fraction of the transcriptome is lacking protein-coding potential. The functional annotation of ...
The L-lactate-specific transporter SfMCT is a model SLC16 family homologue for the determination of inhibitors and potential drugs. Here, starting from a weakly-binding non-transported ligand, nanomolar affinity inhibitors of SfMCT are developed and crystal structures of the transporter-ligand complexe...
(C) Timing of consecutive flower opening in LA1589 starting with the second oldest flower (2). The black bar indicates the percentage of flowers that opened at one-day time intervals at the position on the inflorescence listed on the X-axis. The white bar indicates the percentage of flowers...
However, the representation of cells as circular cavities that contract uniformly (with unrealistic high contraction) in 2D without responding to the propagated mechanical signal, is far from realistic biology. Still, this minimal implementation captures the essence of the experimental system in terms ...