only the testis-specific circRNA from the sex-determining region Y (Sry) was considered functional (in mouse testes) [22,23]. However, in recent years, the adoption of high-throughput RNA sequencing (RNA-seq) and circRNA-specific bioinformatics algorithms has enabled...
In contrast to traditional linear RNAs, circRNAs lack a 3' poly(A) tail and a 5' cap structure, are closed into a ring in the form of covalent bonds and are not sensitive to exonucleases. This unusual structure provides circRNAs with an elevated level of stability. Most circRNAs are ...
Biogenesis and functions of circRNAs.ALariat-driven circularization: after canonical splicing occurs the skipped exons and introns are spliced from the pre-mRNA to form a lariat structure. The intronic sequences are then removed in the internal splicing to form an EcRNA. Intronic lariats that escap...
M6A modification mediates nucleoplasmic transport of circRNAs In recent years, many published articles have shown that individual circRNAs can be transported into the cytoplasm during biogenesis and development, competing with other RNAs for binding by RBPs or miRNAs (Memczak et al. 2013). Therefore...
Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature. 1979;280(5720):339–40. Article CAS PubMed Google Scholar Du WW, Yang W, Liu E, Yang Z, Dhaliwal P, Yang BB. Foxo3 circular RNA retards cell cycle progression via forming ternary ...
It gradually differentiates from mesoderm-derived cells into myoblasts, merges into myotubes, and matures to form muscle fibers [11]. At present, skeletal muscle morphology has been widely measured in pig [12, 13], chicken [14] and sheep [15], while it is rarely studied in rabbit. The ...
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and the P-U learning strategy is applied to predict unknown interaction pairs. For this purpose, the known circRNA-RBP interaction data are collected from CircRic [15], which form the dataset for training and testing the model, respectively. The Schematic diagram of model is shown as Fig.7....
As a new kind of RNA, circular RNA (circRNA) is a endogenous non-coding RNA with circular structure, which has the characteristics of universality, stability, conservatism and specificity. CircRNA can specifically bind to microRNAs (miRNAs) in the form of competitive endogenous RNA, thus directly...
2. The split reads locate at 5′ splice site show the CIGAR values in the form of xS|HyM, while the split reads locate at 3′ splice site show the CIGAR values in the form of xMyS|H. In addition, some circRNAs have complex alignment features. These junction reads may be mapped in ...