Some of these findings have previously been presented in abstract form [16]. Results We found that knockout (KO) pups appeared healthy and grew normally during the first 2 weeks of life. At P16, however, KO pups were smaller than their littermates (-14% vs wild-type (WT), p = 0.0...
Histone acetylation modifications, a common form of epigenetic modification, mainly occur on conserved lysine residues at the H3 and H4 N-terminal tail, which are catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs) [8]. Histone acetylation alters the condensed chromatin int...
OHP-induced neurotoxicity can be divided into two distinct forms, acute and chronic, according to the incidence, symptoms, duration, mechanisms, and other clinical features. Acute OIPN, triggered mainly by cold stimulation, occurs in 85–96% of patients within hours of infusion and lasts for th...
population of type 3 innate lymphoid cells (ILC3) was only identified in the small intestine with the expression of thePTPRC,ETS1,TOX,IL7R,ID2, andRORCgenes (Fig. S1C), as well as pericytes stably expressingKCNJ8,ABCC9, andRGS5(Fig. S1D). In contrast, a small proportion of subpopula...
The LD analysis revealed two genome-wide significant association SNP (Chr1:150612293 and Chr1:150612295) in ERG located in a 12 SNPs LD block (Table S5), while the two other genome-wide significant SNPs did not form an LD block (Figure S4). We identified that a stop-gained mutation (...
thereby promoting the proliferation and migration of CC. E6/E7 regulates the aerobic glycolysis of CC cells through the IGF2BP2-mediated modulation of m6A-MYC mRNA. KCNMB2-AS1 and IGF2BP3 form a positive regulatory circuit, which increases the tumorigenic effect of KCNMB2-AS1 in CC. YTHD...
KCNMA1 is a pore-forming component of BK channels expressed by many cell types that is involved in variety of stimuli and tumor progression [207,208]. It has been observed thatmiR-31increased DDP resistance in OC cells via KCNMA1 suppression [95]. NF-E2-related factor 2 (NRF2) is a re...
NO is generated from L-arginine through one of several NO synthase (NOS) isoforms. The neuronal form (nNOS), which requires calcium/calmodulin for activation, is expressed by subpopulations of neurons throughout the brain [34]. Inducible NOS (iNOS) is expressed by inflammatory cells such as mi...
It is estimated that thousands to tens of thousands of subjects are required to have sufficient power to detect such effect sizes, a prerequisite that has typically not been fulfilled for many association studies in AD until recently. Genetic heterogeneity in the form of both different disease ...
Congenital heart disease (CHD) is the most common form of birth defect and affects approximately 1% of live-born children [1]. It is also among the top five causes of death in children younger than 1 year [2]. Despite improved prenatal care and increased awareness of risk factors, the gl...