Targeted spatial transcriptomics hold particular promise in analyzing complex tissues. Most such methods, however, measure only a limited panel of transcripts, which need to be selected in advance to inform on the cell types or processes being studied. A
Müller-cell-derived cues, such as vascular endothelial growth factor-a (Vegfa), attract the endothelial tip cells to penetrate the retina to form the inner retinal vascular layers [2, 10]. Müller cell specific deletion of transcription factor hypoxia-inducible factor (Hif) 2 alpha or Hif ...
As in many neurodegenerative diseases, AD is one in which polypeptides aggregate to form amyloid deposits. In AD, the aggregates of a protein called, amyloid-β (Aβ) peptide are strongly believed to be the cause for neuronal death and cognitive decline [1]. Primarily two forms of Aβ, ...
decrease in electrical activity in this brain area, which may be associated with the symptoms and therapeutic responses observed in depression [38].Single nucleotide polymorphisms (SNPs), a key form of genetic variation, have significant implications for genetic research and clinical diagnosis [39]. ...
Malignant mesothelioma (MM) is a rare and aggressive form of cancer that affects the mesothelial surfaces, associated with exposure to asbestos fibres. To date, no cure is available for MM and therapeutically approved treatments are based on the use of platinum compounds often used in combination ...
Diabetic retinopathy (DR) is considered a primarily microvascular complication of diabetes. Müller glia cells are at the centre of the retinal neurovascular unit and play a critical role in DR. We therefore investigated Müller cell-specific signalling
(D) Tissue-specific expression profile of the KCNE1 gene. (E) Tissue-specific expression profile of the POPDC2 gene Full size image A total of 28 genes were identified as being associated with these GO terms, and functional analysis of the candidate genes indicated that the positively selected...
We introduced models for explaining the missing variance by considering trans effects of variability in TFs on gene expression in the form of transcriptional variation (TF-Expression) or genetic variation (TF-Binding) in TFs. Here, we applied our models to 49 tissues and cells, characterized the...
Over-expression of miR-31 or loss of KCNMA1 leads to increased cisplatin resistance in ovarian cancer cells. Tumour Biol. 2016;37(2):2565–73. Article CAS PubMed Google Scholar van Jaarsveld MT, et al. miR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells. ...
Similar to CADASIL, cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a genetic form of vascular dementia, caused by mutations in theHTRA1gene [110]. Much like CADASIL, CARASIL affects small penetrating arterioles in the white matter and basal gan...