Tumor cells with a high glycolysis rate produce plentiful lactate which exists in the form of lactate– (Lac–) and H+. Tumor cells rely on MCTs as well as CAs to export redundant protons and lactate and maintain the acid–base balance [302]. In addition, CAIX has been reported to ...
Through data analysis and screening, the authors found that the high expression of EGFR and Src in metastatic renal cell carcinoma could be used as target genes for combined targeted therapy. Moreover, an optimal combination of targeted drugs for mRCC was proposed, which significantly improved ...
The results revealed that GPR65 overexpression led to a reduced potential of HTR-8/SVneo cells to form a tubular network and instead resulted in the aggregation of cells into clumps, particularly at pH 6.5 (Fig. 3C). Therefore, GPR65 inhibits the potential of HTR-8/SVneo cells to form ...
Finally, we tested whether silencing of this gene expression affects the epidermal growth factor receptor (EGFR) signaling pathway in HeLa cells. Methods Reagents A list of all antibodies used in this study can be found in Table 1. Protein G Dynabeads, di-4 ANEPPDHQ (Invitrogen, D36802), ...
[125]. In the context of EGFR, CRISPR-Cas9 can be programmed to target and modify the mutated sequences responsible for cancer growth, potentially inhibiting tumor progression and improving patient outcomes [126]. Editing the EGFR gene using CRISPR-Cas9 can have both positive and negative ...
Additionally, we used the HR for the sustained eGFR decrease < 15 mL/min/1.73 m2 to adjust for the effect of finerenone on progression to CKD 5. As the median follow-up duration in the FIDELIO-DKD trial was 2.6 years, HRs to account for the longer-term risk of a CV event (...
found EVs derived from gliomas could deliver an oncogenic form of EGFR (epidermal growth factor receptor), EGFRvIII [4], and further showed that EVs released by A431, A549 and DLD1 cancer cell lines could transfer EGFR to induce angiogenesis in human umbilical vein endothelial cells (HUVECs) ...
Locoregional recurrence is the dominant form of treatment failure in head and neck (H&N) cancer. The epidermal growth factor receptor (EGFR) is frequently ... AK Gupta,WG Mckenna,CN Weber,... - 《Clinical Cancer Research An Official Journal of the American Association for Cancer Research》 ...
Moreover, the high molecular heterogeneity of GBM tumors, exemplified by unevenly distributed amplifications of EGFR and PDGFR, challenges the effectiveness of receptor tyrosine kinase inhibitors. Analysis of The Cancer Genome Atlas (TCGA) and single-cell RNA-seq further reveals substantial heterogeneity...
Epidermal growth factor receptor (EGFR), the receptor for members of the epidermal growth factor family, regulates cell proliferation and signal transduction; moreover, EGFR is related to the inhibition of tumor cell proliferation, angiogenesis, invasion