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Matuzumab (EMD72000) is a humanized IgG1 monoclonal antibody to the human EGFR. Laboratory studies have shown promising inhibitory effects on tumor growth and angiogenesis, including L3.6pl in an orthotopic rat model [56]. In a phase I study of combined treatment with matuzumab and gemcitabine, ...
One of last year's most frequently cited nephrologic studies, led by Prof. Tobias Huber, UKE Hamburg, showed that the viral load (measured as the number of copies per cell) in the deceased was highest in the respiratory tract and second highest in the kidneys, followed by lower levels in...
IMAGING TO DEFINE DOSE AND/OR SCHEDULE In the clinic, phase I trials usually incorporate a dose-escalation phase in which imaging does not formally have a role, under the assumption that the biggest imaging changes are likely to be detected at the highest dose, and the objective of this ...
The dilution factor (D.F.) is the ratio of the number of different samples that you can expect to get from a given sample size. If you take one of the five samples and multiply it by 3, you will get a sample size of 15.
[3,58,85]. This does not mean, however, that muscle mass should be of less importance when assessing nutritional status, but rather that measurements of muscle strength, that can be easily assessed by HGS, should be incorporated as an important component for the diagnosis of muscle ...
Future value assessment frameworks should consider new trial approaches as they will apply to an increasing number of development scenarios. Similarly, successful precision medicines have opened the door for an increasing number of therapies going to market with single arm phase II data based on ...
What does this mean for applications of AI in drug discovery? AI can, in principle, deliver all of the above aims: it can make decisions faster (predictions are faster than experiments) and more cheaply (predictions cost less than ...
CKD: eGFR > 10 mL/min no change in dose needed. If QTc prolonged on EKG, an alternate drug may be needed. Drug interaction: Conivaptan: could increase concentration ofCYP3A4 substrate. ESRD: Transdermal patch suggested to not be used with ESRD (MW 336; lipophilic; Vd 4 L/kg). CKD:...
During an ex vivo culture of CTC-TJH-01 cells, contaminating blood cells and a small number of CTC underwent rapid cell death. The majority of surviving CTC adhered to the plate, but remained dormant throughout the initial two weeks, suggesting the low in vitro clonogenic potential of CTC. ...