Two-tailed unpaired Student’s t test was used to assess the statistical difference in c–e. Source data are provided as a Source Data file. Full size image Liver inflammatory infiltration is a histological fea
Two-sided t test, ***p < 0.001. Source data Extended Data Fig. 4 Flanking ALU sequences are required to form circ-E-cad RNA; C-E-Cad activates STAT3, AKT and ERK signalling and independent functions of C-E-cad and E-cadherin. (Related to Figs. 3 and 4). a, The ...
A log-rank test shows that there is a statistically significant difference between the treatment groups also when the vehicle group is excluded. Body Weight Body weight gives an indication on how severe the side effects of the treatment are, poor development of body weight indicating more adverse...
To test the synergistic effect of quercetin and gefitinib on EGFRT790M-harboring NSCLC in vivo, H820 or H1975 cells were subcutaneously injected into nude mice and administered with vehicle, 40 mg/kg/day of quercetin, 5 mg/kg/day of gefitinib, or combination of quercetin and gefitinib. When...
Full size image Formo suppresses EGFR signaling ex vivo and in vitro To determine the anti-tumor mechanisms of Formo, we first examined the effect of Formo on EGFR signaling. Using the in vitro pulldown assay, we analyzed the interaction between Formo and EGFR WT/activating mutants (Del E7...
To test for the involvement of MMP’s in the expression of COX-2 induced by TNF-α and LPA, 18Co cells were treated with TNF-α and LPA in the presence or absence of the broad-spectrum MMP inhibitors GM6001 and BB-94, which inhibit multiple MMP’s and ADAMs. Both BB-94 and GM...
We similarly observed weak phosphorylation of full-length HER2 ΔLRENT relative to HER2 WT but observed elevated pERK levels, possibly due to heterodimerization with endogenous EGFR in 293T cells (Figure S1D). To test heterodimerization dependence more directly, we established an assay to measure ...
centrally confi rmed using the cobas EGFR Mutation Test (Roche Molecular Systems Inc, Pleasanton, CA, USA; Research in context Evidence before this study We searched PubMed for reports in English, using the terms “NSCLC” and “EGFR T790M mutation”, and fi ltered by clinical trial...
Full size image To test the importance of PRMT1 methyltransferase activity for colon tumorigenesis in vivo, we utilized the PRMT1 inhibitor AMI-1 [53, 57] to inhibit its methyltransferase activity. We demonstrated that the AMI-1 treatment could mimick the phenotypes caused by the PRMT1-Δ on ...
Screening with an eGFR test may also be done if you are going to donate a kidney. The test can help ensure you have sufficient kidney function to donate safely and screen for problems after donation. Doctors may prescribe an eGFR test as a form of screening before some medical procedures, ...