描述:Recombinant Human EGFR is produced by our Mammalian expression system and the target gene encoding Leu25-Ser645 is expressed with a 6His tag at the C-terminus. Accession:P00533 中文别名:EGFR蛋白; ErbB1蛋白; HER1蛋白 来源:Human Cells ...
Diverse mis-sense mutations found in all regions of theTP53gene frequently engender mutant proteins that lose tumor suppressive functions, and/or gain new oncogenic properties. The degree of loss of tumor suppressive functions, versus the context-dependent manifestation of gain-of-function (GOF) pheno...
The cell signaling factors EGFR, EphA2, and Ephexin1 are associated with lung and colorectal cancer and play an important role in tumorigenesis. Although the respective functional roles of EGFR and EphA2 are well known, interactions between these protein
Pellino-1 (PELI1) is an E3 ubiquitin ligase acting as a key regulator for the inflammation and autoimmunity via the ubiquitination of the substrate proteins. There is increasing evidence to support that PELI1 functions as an oncoprotein in tumorigenesis
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability, intratumoral histopathological variability... Y Liang,M Diehn,N Watson,... - 《Proc Natl...
Full size image Formo suppresses EGFR signaling ex vivo and in vitro To determine the anti-tumor mechanisms of Formo, we first examined the effect of Formo on EGFR signaling. Using the in vitro pulldown assay, we analyzed the interaction between Formo and EGFR WT/activating mutants (Del E7...
AP-1 functions as a dimer in the form of c-Fos/c-Jun or c-Jun/c-Jun. The nuclear localization of c-Fos was decreased by EGF antibody, AG1478, and U0126, whereas that of c-Jun was unaffected by these drugs (Fig. 6C and D). However, the involvement of c-Jun was demonstrated ...
Oncogenic events circumvent the kinase activation process through a variety of mechanisms, including point mutations (e.g., BRAF V600E, EGFR L858R), in-frame deletions or insertions (e.g., EGFR exon 19 deletions or exon 20 insertions), amplifications (e.g., ERBB2), and gene fusions (e...
Full size image Discussion In these studies, we sought to identify transcriptomic changes that accompany the development of EGFRi resistance in basal-like TNBC PDXs in order to identify biomarkers and gene signatures predictive of EGFRi response. In pilot studies, we identified an EGFRi that demons...
and transfected them into Huh7 cells to screen for their ability to upregulate FUT8 expression. Among the 10 HCV gene expression plasmids, pcDNA3.1-E2 transfection caused the most significant upregulation of FUT8 protein expression (Fig.1d), and the dual-fluorescence reporter gene experiment also...