The buccohypophyseal canal (BHC) is a peculiar duct connecting the floor of the diencephalon and the adenohypophysis with the roof of the mouth. In all mammals, it closes in the early stages of development (embryonic day (E) 11.5 in CD1 mice). Its persistence in humans represents an abnorm...
Diekman EF, Boelen CCA, Prinsen BHCMT, IJlst L, Duran M, de Koning TJ, et al. Necrotizing enterocolitis and respiratory distress syndrome as first clinical presentation of mitochondrial trifunctional protein deficiency. 2012. p. 1–6. Rusconi B, Warner BB. The hidden treasure of neonatal scr...
MECP2maps to chromosome Xq28, includes four exons, and encodes the methyl CpG binding protein 2 (MECP2) (NM_004992.4). The protein fine tunes the expression of thousands of genes in the brain by binding to methylated cytosines predominantly in the CG and CAC context [1,2,3]. Loss-of-...
BHC and MMY had performed the laboratory analysis. NNC and GBJ participated in the design of the study, performed the laboratory analysis and improved the final version of this manuscript. OAMC participated in the design of the study, supervised the study and substantially revised the first draft...
By adding a new layer of complexity to RNA biology, circRNA may be an integral regulatory entity required to develop and maintain multiple distinct mammalian cell types and organs from the same genetic information. In Drosophila, neural levels of circRNAs were found to increase throughout life, ...
Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a simple protocol for detection of open chromatin. Computational footprinting, the search for regions with depletion of cleavage events due to transcription factor binding, is poorly u
Histone demethylase LSD1 plays key roles during carcinogenesis, targeting LSD1 is becoming an emerging option for the treatment of cancers. Numerous LSD1 inhibitors have been reported to date, some of them such as TCP, ORY-1001, GSK-2879552, IMG-7289, IN
NEPC is rarely diagnosed de novo in its pure form (small cell or large cell prostate cancer, < 2% of first diagnoses) [10], but about 10-17% of patients with metastatic CRPC have been reported to progress with t-NEPC when treated with NHA [11]. Increased therapeutic pressure on the...
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies that are considered as a global health challenge. Despite many progresses in therapeutic methods, there is still a high rate of mortality rate among CRC patients that is as
Pozuelo Rubio M, Geraghty KM, Wong BHC, Wood NT, Campbell DG, Morrice N, Mackintosh C: 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking. Biochem J. 2004, 379 (2): 395-408. 10.1042/BJ200317...