Diekman EF, Boelen CCA, Prinsen BHCMT, IJlst L, Duran M, de Koning TJ, et al. Necrotizing enterocolitis and respiratory distress syndrome as first clinical presentation of mitochondrial trifunctional protein deficiency. 2012. p. 1–6. Rusconi B, Warner BB. The hidden treasure of neonatal scr...
MECP2maps to chromosome Xq28, includes four exons, and encodes the methyl CpG binding protein 2 (MECP2) (NM_004992.4). The protein fine tunes the expression of thousands of genes in the brain by binding to methylated cytosines predominantly in the CG and CAC context [1,2,3]. Loss-of-...
Prior to the discovery of the first demethylase LSD1 (also named KDM1A, KIAA0601, BHC110, and AOF2) in 2004 [4], the process of histone methylation is considered to be irreversible. LSD1 specifically demethylates histone lysine residues H3K4me1/2 and H3K9 me1/2 (Fig. 1a). LSD2 (...
Recently a powdered form of micronutrients has been developed which may decrease side-effects and thus improve adherence. However, before testing the efficacy of the supplement as an alternate choice for supplementation during pregnancy, the bioavailability of the iron needs to be determined. Our ...
The worldwide resurgence of bed bugs [both Cimex lectularius L. and Cimex hemipterus (F.)] over the past two decades is believed in large part to be due to the development of insecticide resistance. The transcriptomic and genomic studies since 2010, as w
This review analyzes the literature of bone grafts and introduces tissue engineering as a strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; analyzed characteristics, advantages, and limitations of the grafts; and
form of the disease, an ortholog in a mouse model that exhibits a cognate phenotype, or annotation with a GO term that is held by other genes associated with the disease of interest. We then apply two rounds of machine learning. The purpose of the first round is to limit and refine the...