Sign in to download full-size image FIGURE 10.2.Upper panels: schematic representations of MHC class I and MHC class II molecules. The orientation of these molecules at the cell surface is indicated, as are the domain structures of the extracellular portions of the proteins, the membrane-spanning...
Sign in to download full-size image Fig. 1.The Roman God Janus is always portrayed with two faces in opposite directions. Thereby, he represented an intermediary between two worlds. Qa-1/HLA-E molecules have an important function in innate immunity through interacting with innate, invariable CD...
Genes within the MHC involved in antigen presentation constitute the most polymorphic loci known in vertebrates [52,53]. The variability of the MHC-molecules is correlated with the diversity of the T-lymphocyte receptors which in turn determine the disease and parasite resistance of an organism and...
Genes within the MHC involved in antigen presentation constitute the most polymorphic loci known in vertebrates [52,53]. The variability of the MHC-molecules is correlated with the diversity of the T-lymphocyte receptors which in turn determine the disease and parasite resistance of an organism and...
Full size table MHC associations revealed by genome-wide association studies (GWAS) can often not be fine-mapped to a single allele at a single locus; rather they comprise independent effects from multiple loci (see “Role of MHC variants in human diseases”). The presence of these multiple,...
The PARRIS method infers positive selection acting on nucleotide sequences by using likelihood ratio tests (LRT) to compare a null-model (M1, no-selection) where dN is restrained to be ⩽ dS, against a full model (M2, selection) where dN is allowed to be 4dS. This method expands on ...
Full size table MHC associations revealed by genome-wide association studies (GWAS) can often not be fine-mapped to a single allele at a single locus; rather they comprise independent effects from multiple loci (see “Role of MHC variants in human diseases”). The presence of these multiple,...
The La-PCR results (Figure S1b) agree with manual assembly in the Core Region Sequence and phylogenetic analyses. Class II genes. We obtained the full-length cDNA sequences of all Nini-IIa and -IIb genes (Figure S2). These cDNA sequences perfectly match the class II haplotypes obtained by...
Full size image To investigate the distribution of allele groups with respect to the combinations of N- and C-terminal clusters, we plotted the combination heatmap in Fig.5a(Supplementary Fig.8for HLA-A and -C and Supplementary Data8), which in total has 35 combinations (7 N-terminus ×...
Genetic ablation of the HLA-DR α-chain rendered cells resistant to infection by bat influenza A virus, whereas ectopic expression of the HLA-DR complex in non-susceptible cells conferred susceptibility. Expression of MHC-II from different bat species, pigs, mice or chickens also conferred ...