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The use of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) in cancer therapy has the potential to revolutionize the way for treating different diseases [1]. CRISPR technology allows for precise and efficient manipulation of the genome, and its application in cancer research has the ...
One would anticipate, given the function of NK cell receptors in recognition of MHC class 1 proteins, that there must be some unique feature to this interaction in the pig to allow NK cells to function irrespective of unlinked polymorphism and the SLA loci. Immune gene family expansion A ...
Splenic macrophages have increased expression of major histocompatibility complex (MHC)-II and CD86 and can also present autoantigens to Th cells. CD8+ cytotoxic T lymphocytes (CTLs) can directly lyse platelets or induce platelet apoptosis. Moreover, autoantibodies and CTLs interfere with ...
The MHC class II molecules are symmetrical heterodimers, consisting of one alpha chain and one beta chain, with non-covalent contacts in which the alpha1 and beta1 domains form a peptide-binding region (PBR). In mammals, MHC class II genes are constitutively expressed in antigen-presenting cell...
BACKGROUND: The study was carried out to evaluate the expression of major histocompatibility complex (MHC) molecules in retinal transplants with different tissue integrity. METHODS: Twelve adult rabbits received an allogeneic subretinal neuroretinal transplant, in the form of either fragmented embryonic ...
immune cells during inflammation and immune responses [67], and with the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, RANTES also induces the proliferation and activation of certain natural-killer cells to form CC-chemokine-activated killer cells [68]...
In addition to the high immune heterogeneity of tumor cells, the heterogeneity of other cell types further increases the complexity of tumor tissue. These different types of cells form a complex interaction network through ligand-receptor interaction, paracrine, autocrine, and other intercellular ...
following DNA damage and could be released by cancer cells to involve NKp30 to activate NK cells [136]. Exosome-release BAT3 could promote the crosstalk between NK cells and dendritic cells, while plasma-soluble BAT3 suppresses NK cell activation by competing with an exosomal form of BAT3 [...
Here, we describe our findings concerning the expression of MHC II as a marker of microglia senescence and NLRP3 inflammasome in bovine brains and the cross-talk between inflammasome, autophagy and ROS production. Samples of hippocampus were collected from 42 Podolica cattle. Animals were divided ...