For example, iron significantly contributes to mitochondrial function in adenosine triphosphate (ATP) production or synthesis, RNA and deoxyribonucleic acid (DNA) repair, cell survival, and ferroptosis [42, 43]. In addition, this valuable element is vital for the multiplication of viruses. On the ...
Traditional Chinese medicine uses various herbs for the treatment of various diseases for thousands of years and it is now time to assess the characteristics and effectiveness of these medicinal plants based on modern genetic and molecular tools. The her
However, the original L858R/T790M mutation was present but at lower levels in 67R and AZDR (Supplementary Fig. 2c). As bypass signaling is a common form of resistance to kinase inhibitors, we sought to identify potential kinases that are activated in ASK120067-resistant cells. We performed ...
The ATP-binding cassette (ABC) transporter superfamily is one of the largest transporter gene families and is observed in all animal taxa. Although a large set of transcriptomic data was recently assembled for several species of crustaceans, identificati
By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your perso...
While electrons obtained from the oxidation of sulfide, thiosulfate, and, possibly, elemental sulfur by Sox and rDsr are shuttled into the electron transport chain, energy obtained from the oxidation of sulfite is immediately available in the form of ATP. Bioenergetics The S. velum symbiont is ...
Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMPK. However, the role of
As cellular swelling persists, the permeabilized membrane ultimately ruptures and releases an ample quantity of cellular contents and inflammatory mediators, including IL-18, NF-κB, IL-1β, ATP, HMGB1, etc [15]. Of note, IL-1β can stimulate dendritic cell (DC) maturation and monocyte ...
Chalkiness is a common phenotype induced by various reasons, such as abiotic stress or the imbalance of starch synthesis and metabolism during the development period. However, the reason mainly for one gene losing its function such as NAC (TFs has a larg
Each heavy chain is comprised of an N-terminal motor domain that contains the ATP- and actin-binding sites, an intermediate rod domain that dimerizes to form an α-helical coiled-coil and a C-terminal tailpiece. Despite the fairly high sequence conservation between the non-muscle myosin-II ...