Mantle cell lymphoma (MCL) is a subtype of Non-Hodgkin lymphoma (NHL) of mature B-cells characterized by translocation, which is typically due to excess expression of Cyclin D1. Although with the progress in our knowledge of the causes for MCL and availa
Microbiome alterations have been associated with depression, and fecal transfer of depressed patients’ microbiomes is sufficient to enhance despair behaviors in rodents. Yet little is known about the potential mechanisms, whereby microbes modulate depre
The IL-11 activity is determined by the expression of the IL-11R receptor alpha (IL-11Rα) and the signal transducing subunit β (gp130) on the cell membrane. A recombinant soluble form of the IL-11Rα (sIL-11Rα) in combination with IL-11 acts as an agonist on cells expressing ...
2g). Similarly, full-length coverage with Smart-seq3xpress resulted in significantly (2–5-fold) increased read support over exon–exon and exon–intron splice junctions, which form the basis for RNA velocity inference16 (Fig. 2h). To perform a direct comparison of cluster granularity, we ...
SARS-CoV-2 recognizes the ACE2 receptor on the host cell membrane via the RBD of spike protein, and enters host cell. Once uncoating, the viral genomic RNA will be used to synthesize the genomic RNA (- sense). Next, the genomic RNA is used as a template to form genomic and ...
Intriguingly, Foxp3+ regulatory T cells (Tregs) were less sensitive to ATG depletion and remained at higher levels following in vivo recovery compared to controls. Of note, the frequency of Foxp3+ Tregs with memory T cell phenotype was significantly increased in ATG-treated animals. Conclusion ...
of cell death in response to accidental injury stimuli [3]. However, RCD is characterized by controlled signaling pathways that play key roles in organismal development or tissue renewal [4]. Previously, apoptosis was thought to be the major form of RCD, but with more in-depth study on ...
[51]; nsp3 is a papain-like protease for viral polyprotein processing; nsp4 and nsp6 form double membrane vesicles (DMVs) associated with replication–transcription complexes; nsp5 is a 3C-like protease for viral polyprotein processing; nsp7 and nsp8 are accessory factors of RdRP; nsp8 ...
Given that purified cellular RNA can self-assemble in vitro to form assemblies that closely recapitulate the transcriptome of stress granules and the stress granule transcriptome is dominated by lncRNAs [63, 144], it is likely that the RNA-RNA interactions mediated by abundantly expressed lncRNAs ...
In the form of intravenous pulse methylprednisolone (MP), systemic corticosteroids were given to some patients with SARS-CoV infection for several reasons [174]. First, it was hypothesized that the clinical progression of pneumonia and respiratory failure associated with the peak viral load of SARS-...