71 In addition, the ATG16L1 (T300A) mutation increases susceptibility to caspase-3 processing of ATG16L1, leading to decreased levels of the full-length protein following dysfunctional autophagy.71 Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of mucosal tissues in ...
Two main autophagy pathways have been implicated in host defence against intracellular pathogens: the canonical pathway of xenophagy1,2,3and a non-canonical pathway named LC3-associated phagocytosis (LAP)4,5. Xenophagy is a specialized form of macroautophagy in which de novo autophagosome biogenesis ...
and plays an essential role in the initiation of autophagy23. Next, we sought to determine the functions of LD targeting by ATG14. Knockdown of ATG14 caused the accumulation of LDs in untreated cells (Fig.1i). Overexpression of ATG14, but not ATG14WFY-RRR, led to the decreased LD numbe...
Arrows indicate the presence of full-length L1 (L1 fl) and of the 70 kDa L1 fragment (L1-70), or of p62, ATG12, and ATG12 in complex with ATG8. Arrowheads indicate bands corresponding to the light and heavy antibody chains and proteins bands that could not be identified. 2.3. The...
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Full size image ATG therapy differentially depletes naive and memory T cells from the peripheral blood and spleen It is still a matter of debate whether ATG therapy preferentially depletes certain subsets of T cells [4, 14–17]. In these experiments, we investigated changes of naive and memory...
Full size image Similarly, we sought to address whether SETD2 has an impact on ATG14 protein levels. For this purpose, immunoblot analyses of ATG14 performed in HeLa cells allowed the detection under control conditions of two distinct protein bands that upon BafA1 treatment led to the accumulat...
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