DR.SC employs a two-layer hierarchical model that simultaneously performs dimension reduction and spatial clustering, optimizing the extraction of low-dimensional features as well as the identification of spatial clusters. The BANSKY algorithm clusters cells using an azimuthal Gabor filter (AGF)-inspired...
The proteins selected for fusions with CBD were highly reengineered, or ‘artificial’ (= not existing in Nature), which carried condensed functionalisation in the form of concatemers. These were composed of repetitive, bioactive epitopes, oriented in organised head-to-tail fashion, expressed ...
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Informed consent was waived by the University of the Witwatersrand Human Research Ethics as the data was being collected for the national pandemic surveillance program and was shared in de-identified form. Only de-identified data obtained from the National Institute for Communicable Diseases (NICD) ...
the IMM invaginates into the mitochondrial matrix to form cristae, the crucial structure for mitochondrial function [66]. To maintain these structures, mitochondria undergo multiple complex processes (including fission and fusion) to dynamically control the function of mitochondria under various stimuli ...
Particularly, arterial hiPSC-ECs can form a more extensive capillary network in vivo [28]. In general, though hiPSC-ECs provide a novel notion, their scientific and therapeutic potential still remain to be carefully assessed in clinical application (Figure 6). Figure 6 Induced pluripotent stem ...
Inhalation of these particles are associated with the promotion of inflammatory processes and oxidative stress [20, 21]. Immunopathology of SLE comprises the production of autoantibodies, mainly against nuclear antigens, that form immune complexes (IC). These IC deposit in tissues and vessels ...
Genetically susceptible individuals form anti-citrullinated protein antibodies (ACPAs) as part of a loss of tolerance to citrullinated and other posttranslationally modified proteins. As inflammation increases secondary to the loss of tolerance, the levels of inflammatory cytokines such as tumor necrosis ...
The sponsor form this trial is the Cardiff and Vale Local Heath Board (formerly the University of Wales NHS Trust) Cardiff, Wales, UK. Authors' contributions All authors have been involved in the design of the study and the drafting of the manuscript and will participate in patient recruitment...
We exposed retinal explants to Treg secretome in the presence or absence of a pro-inflammatory stimulus in the form of lipopolysaccharide (LPS) and investigated cone survival by staining for CA. LPS is a widely used pro-inflammatory activator of microglia and macrophages [33], which at least ...