作为FTLD的一种亚型,伴有TDP-43阳性包涵体的FTLD(FTLD-TDP)的特点是具有某些临床症状和病理神经元包涵体,这种TDP-43阳性包含物可通过TAR DNA结合蛋白(TDP-43)免疫反应加以检测。 根据TDP-43的分布和形态,FTLD-TDP可分为5个亚型:A型FTLD-TDP、B型FTLD-TDP、C型FTLD-TDP、D型FTLD-TDP和E型FTLD-TDP,这些亚型与潜...
FTLD-TDP with motor neuron disease and progressive supranuclear palsy-like syndrome: a distinct phenotype?gaze palsy, and a behavioral variant of frontotemporal dementia, associated with eitherclinically possible or definite MND. Neuropathological examination revealed hallmarks of FTLD-TDP with major ...
FTLD-TDP with motor neuron disease, visuospatial impairment and a progressive supranuclear palsy-like syndrome: broadening the clinical pheno- type of TDP-43 proteinopathies. A report of three cases. BMC Neurol 2011;11:50.Rusina R, Kovacs GG, Fiala J, Hort J, Ridzon P, Holmerova I, et ...
编码TDP-43的基因TARDBP的罕见突变导致ALS和FTLD的显性遗传形式,这表明TDP-43功能障碍会导致神经变性,以及聚集体TDP-43病理学的程度与神经元丢失相关。由TDP-43聚集导致的疾病机制与TDP-43在细胞核中的相互作用的丧失和在细胞质中的异常相互作...
In addition, trunsduction of these pathological TDP-43 from brains of patients into cells induced TDP-43 aggregation. Conclusions The results suggested that spreading of prion-like abnormal TDP-43 may account for the pathogenesis and progression of FTLD-TDP-43....
03:52 Nature—科学家发现NPTX2是ALS/FTLD中介导TDP-43神经毒性的关键因子 01:38 Cell Stem Cell—新冠病毒感染可以引起神经细胞衰老 02:00 Lancet Neurol—每天口服1粒阿托吉泮,就可以预防偏头痛的发作 02:40 Nat Neurosci—帕金森病研究重磅:科学家揭示了介导PD患者转弯步态障碍的关键神经环路机制 04:29 Nat ...
jackhump/FTLD-TDP_analysisPublic NotificationsYou must be signed in to change notification settings Fork0 Star2 Files html FTLD_differential_expression_pmi_files FTLD_pca_files FTLD_atrophy_correlations.html FTLD_deconvolution_results.html FTLD_differential_expression.html ...
Background: To evaluate the CSF p-Tau181/Tau ratio to distinguish between the two main forms of frontotemporal lobar degeneration (FTLD): FTLD with TAR DNA-binding protein 43 (TDP-43) immunoreactive inclusions (FTLD-TDP) and FTLD with Tau inclusions (FTLD-Tau). Methods: Differences in the ...
An autopsy-verified case of FTLD-TDP type A with upper motor neuron-predominant motor neuron disease mimicking MM2-thalamic-type sporadic Creutzfeldt-Jakob... An autopsy-verified case of FTLD-TDP type A with upper motor neuron-predominant motor neuron disease mimicking MM2-thalamic-type sporadic ...
Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypesPATHOLOGYFRONTOTEMPORAL lobar degenerationAMYOTROPHIC lateral sclerosisActa Neuropathologica -doi:10.1007/s00401-019-02024-wYasushi NishihiraTamar Gefen...