Distinct pathological subtypes of FTLD-FUS. Acta Neuropathol. 2011; 121 :207–218. doi: 10.1007/s00401-010-0764-0. [ Cross Ref ]Mackenzie IR, Munoz DG, Kusaka H, Yokota O, Ishihara K, Roeber S, Kretzschmar HA, Cairns NJ, Neumann M. Distinct pathological subtypes of FTLD-FUS. Acta ...
Transportin 1: a marker for FTLD-FUS. Acta Neuropathol. 2011; 122 :591–600.Brelstaff J, Lashley T, Holton JL, Lees AJ, Rossor MN, Bandopadhyay R, Revesz T (2011) Transportin1: a marker of FTLD-FUS. Acta Neuropathol 122(5):591-600...
Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disease, which is now classified to three major molecular subgroups based on histopathological findings: FTLD-tau, FTLD-TDP-43, or FTLD-FUS. Before the discovery of TDP-43 in 2006, most tau-negative FTLD cases were collectively termed...
To conclude, the neuroimaging results and the presence of chorea lead to a diagnosis of probable FTLD-FUS in the here presented case. The absence of other typical clinical features of FTLD-FUS, at the moment of presentation, could be explained by the fact that the patient was still in a ...
Acta Neuropathologica Communications https://doi.org/10.1186/s40478-019-0673-y (2019) 7:18 RESEARCH Open Access Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS Lauren M. Gittings1,2,3, Sandrine C. Foti1,2, Bridget C. Benson1,2, Priya Gami...
FUS is an RNA/DNA-binding protein involved in multiple steps of gene expression and is associated with amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration (FTLD). However, the specific disease-causing and/or modifying mechanism med
Neuropathologic characterization of atypical FTLD with FUS-Immunoreactive inclusionsNeuropathologic characterization of atypical FTLD with FUS-Immunoreactive inclusionsS., SpinaR.M., RichardsonJ.R., MurrellP., PietriniE.M., WassermannJ., GrafmanB...
Fused in sarcoma (FUS) was identified as a component of typical inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In FTLD, both nuclear and cytoplasmic inclusions with wild-type FUS exist, while cytoplasmic inclusions with a mutant-form of FUS occur in...
突变和聚集蛋白FUS与两种神经退行性疾病有关:肌萎缩性侧索硬化( ALS )和额颞叶变性( FTLD )。Ludo Van Den Bosch教授( VIB - KU Leuven )领导的研究人员利用一种新开发的果蝇模型,放大了FUS的蛋白质结构,以更深入地了解FUS是如何引起神经元毒性和疾病的。
Atypical FTLD-FUS associated with ALS-TDP: A case report. Neuropathology 2013; 33:83-88Kobayashi Z, Arai T, Yokota O, Tsuchiya K, Hosokawa M, Oshima K, Niizato K, Akiyama H, Mizusawa H. Atypical FTLD-FUS associated with ALS-TDP: a case report. Neuropathology. 2013;33:83-6. doi:...