When compared to wild type animals, mice carrying the Foxp3fgfp allele spontaneously delay, reduce or prevent primary tumor growth, decrease metastasis growth and potentiate the response to anti〤TLA4 monotherapy. These findings suggest allelic variances at the Foxp3 locus may serve as predictive ...
Fig1. Expression of GFP on Tregs in Blood and Spleen in Foxp3-IRES-DTRGFP KI mice. Fig2. Percentages of Tregs in the peripheral blood and spleen of Foxp3-IRES-DTRGFP KI mice treated with diphtheria toxin (DT). Fig3. The percent of Treg+ and other immune cells in peripheral blood of...
Fig2. Percentages of Tregs in the peripheral blood and spleen of Foxp3-IRES-DTRGFP KI mice treated with diphtheria toxin (DT). Fig3. The percent of Treg+ and other immune cells in peripheral blood of MC38 tumor-bearing Foxp3-IRES-DTRGFP mice is detected by FACS.(In collaboration with ...
Fig2. Percentages of Tregs in the peripheral blood and spleen of Foxp3-IRES-DTRGFP KI mice treated with diphtheria toxin (DT). Fig3. The percent of Treg+ and other immune cells in peripheral blood of MC38 tumor-bearing Foxp3-IRES-DTRGFP mice is detected by FACS.(In collaboration with ...
Here, we found that GFP-FoxP3 knock-in (KI) mice showed alterations in the production of anti-nuclear autoantibodies (ANAs) and nephritis with different extent, depending on the presence or absence of lupus susceptibility gene locus 1 (Sle1) and KI method: contrasting with B6.Sle1.fGFP-...
Tg4 FoxP3gfp mice are not more susceptible to induced disease.Johan VerhagenBronwen R. BurtonGraham J. BrittonElla R. ShepardStephen M. AndertonDavid C. Wraith
Here, we found that GFP-FoxP3(+) knock-in (KI) mice showed alterations in the production of anti-nuclear autoantibodies (ANAs) and nephritis with different extent, depending on the presence or absence of lupus susceptibility gene locus 1 (Sle1) and KI method: contrasting with B6.Sle1.f...
Genetic lineage tracing of Foxp3+ Treg cells in BAC-Foxp3Cre-GFP × R26Y mice.Sonja, Schallenbergx 104 (□), 1 x 105 (○), 5 x 105 (◇), or 1 x 106 (△) BM cells from C57BL/6-GFP mice.