Foxp3-DTR-EGFP小鼠是一种在免疫学研究中广泛使用的转基因小鼠模型,这些小鼠在Foxp3基因座上插入了白喉毒素受体(DTR)和增强型绿色荧光蛋白(EGFP)基因。这种设计使得研究人员能够通过注射白喉毒素(DT)特异性地去除表达Foxp3的调节性T细胞(Tregs),并通过EGFP追踪这些细胞。
Foxp3-IRES-DTREGFP(LEW) 品系全名 LEW-Foxp3em1(IRES-DTREGFP-WPRE-pA)Smoc 目录号 NR-KI-232394 品系状态 活体 导出PDF 基因信息 基因名 Foxp3 基因曾用名 RGD1562112 染色体位置 X NCBI ID 317382 RGD ID 1562112 Ensembl ID ENSRNOG00000011702 ...
FOXP3突变穿细胞膜活性目的:构建,表达并纯化含有蛋白转导结构域(protein transduction domain,PTD),eGFP的小鼠Foxp3突变体(PTD-eGFP-△E250 mFoxp3)融合蛋白,为研究小鼠Foxp3的功能奠定基础.方法:利用重叠延伸PCR方法构建pET28a-PTD-eGFP-△E250 mFoxp3原核表达载体,并在大肠埃希菌Rosetta(DE3)中表达此融合蛋白,经...
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PTD-eGFP-△E250 mFoxp3融合蛋白的表达与穿膜能力鉴定
目的:构建、表达并纯化含有蛋白转导结构域(protein transduction domain,PTD)、eGFP的小鼠Foxp3突变体(PTD-eGFP...
金致和 GENEANDPEACE 小鼠品系说明书 STOCK Foxp3tm9(EGFP/cre/ERT2)Ayr/J 品系编号:GAP1085 品系简称:Foxp3eGFP-Cre-ERT2 品系特点: Foxp3EGFP-cre-ERT2 小鼠通过 IRES 连接了增强型绿色荧光蛋白 (EGFP), 该蛋白与 P3 (Foxp3) 基因的终止密码子下游的 CreERT2 融合基因融合. 该小鼠有助于研究调节性...
CD4 + and CD8 + regulatory T cells characterization in the rat using a unique transgenic Foxp3-EGFP modeldoi:10.1101/2021.12.09.471889Severine MenoretLaurent TessonSeverine RemyIgnacio Anegon
Rescue of Foxp3 Deficiency by Inducible Activation of a Bicistronic Foxp3/EGFP Alleleasthmarespiratory syncytial virusrhinovirusallergenpreventionexacerbationinceptiontreatmentAsthma is a heterogeneous disorder that is characterized by variable airflow obstruction, airway inflammation and hyperresponsiveness, and ...
Identification of the origin of CD4+ Foxp3+ Treg cells that increased in recipients using ex vivo-expanded Treg cells from eGFP+ (H-2b) mice.EunSol, LeeJungYeon, LimKeonIl, ImNayoun, KimYoungSun, NamYoungWoo, JeonSeokGoo, Cho