6. Bettelli, E.et al.(2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.Proc Natl Acad Sci U S A102, 5138-5143...
该基因编码的蛋白质是转录调节器叉头/翼螺旋家族的成员。这种基因的缺陷是导致免疫缺陷的原因:多内分泌疾病、肠病、X连锁综合症(IPEX),也称为X连锁自身免疫性免疫缺陷综合症。另外,还发现了编码不同亚型的剪接转录变体。The protein encoded by this gene is a m
FOXP3 gene polymorphisms in preeclampsia[J] . Torri D. Metz,Lesa M. Nelson,Gregory J. Stoddard,Robert M. Silver.American Journal of Obstetrics and Gynecology . 2012 (2)Metz TD,Nelson LM,Stoddard GJ,et al.FOXP3 gene polymorphisms in preeclampsia[J].Am J Obstet Gynecol,2012,206(2):165-...
近日,来自日本大阪大学的Shimon Sakaguchi在Immunity上发表了论文Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity。在本研究中,作者探究了Ikzf1与...
FOXP3 (forkhead box P3) 该基因编码的蛋白质是转录调节器叉头/翼螺旋家族的成员。这种基因的缺陷是导致免疫缺陷的原因:多内分泌疾病、肠病、X连锁综合症(IPEX),也称为X连锁自身免疫性免疫缺陷综合症。另外,还发现了编码不同亚型的剪接转录变体。 The protein encoded by this gene is a member of the ...
Foxp3 Overview and Reagents What is Foxp3? Foxp3 is the “master transcriptional regulator” for CD4+regulatory T cells (Tregs)[1,2]. Naïve and memory CD4+T cells can be differentiated into Tregs with induced expression of the Foxp3 gene [3]. Mutati...
Foxp3 is the “master transcriptional regulator” for CD4+regulatory T cells (Tregs)[1,2]. Naïve and memory CD4+T cells can be differentiated into Tregs with induced expression of the Foxp3 gene [3]. Mutation in the Foxp3 gene results in hyperactive ...
基因序列:NCBI_Gene:317382 蛋白序列: UniprotKB:D3ZKI1 UniprotKB:D4Q8I2 UniprotKB:D4Q8I3 大鼠Rat Foxp3 靶点分子功能(预测) Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; NFAT protein binding activity; and enzyme binding activ...
M ETH?ODS : W e cl oned mouse Foxp3 gene into l entiviral vector( pGC?FU) and acquired the plasmid pGC?FU?Foxp3. PCRand sequencing analysiswere made for verifying the positiveThe virus packaging plasmids ( pGC?FU?Foxp3,clones .pHelper1. 0 and pHel per2. 0) were contransfected ...
GENE enhancersThe article focuses on a study conducted by Samstein and colleagues which shows that differentiation of regulatory T (TReg) cells does not involve changes in the accessibility of enhancers targeted by the transcriptional regulator FOXP3....