*使用本品系发表的文献需注明: Foxp3-IRES-DTRGFP mice (Cat. NO. NM-KI-190046) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 Fig1. Expression of GFP on Tregs in Blood and Spleen in Foxp3-IRES-DTRGFP KI mice. Fig2. Percentages of Tregs in the peripheral blood and...
When compared to wild type animals, mice carrying the Foxp3fgfp allele spontaneously delay, reduce or prevent primary tumor growth, decrease metastasis growth and potentiate the response to anti〤TLA4 monotherapy. These findings suggest allelic variances at the Foxp3 locus may serve as predictive ...
Fig3. The percent of Treg+ and other immune cells in peripheral blood of MC38 tumor-bearing Foxp3-IRES-DTRGFP mice is detected by FACS.(In collaboration with CrownBio) Fig4. The percent of Treg+ and other immune cells in spleen and tumor of MC38 tumor-bearing Foxp3-IRES-DTRGFP mice ...
Fig3. The percent of Treg+ and other immune cells in peripheral blood of MC38 tumor-bearing Foxp3-IRES-DTRGFP mice is detected by FACS.(In collaboration with CrownBio) Fig4. The percent of Treg+ and other immune cells in spleen and tumor of MC38 tumor-bearing Foxp3-IRES-DTRGFP mice ...
To identify small molecules that reprogram TH17 differentiation towards iTreg cellfate, we screened 10,000 small molecules using CD4+ naive T cells from IL-17F–RFP/FOXP3–GFP mice cultured under optimal TH17 differentiation conditions. A small molecule, (aminooxy)acetic acid(AOA), was found to...
Figure 2.Localization, marker gene expression and DNA methylation status of exFoxp3 T cells in arthritic mice. Results are shown from fate mapping analyses of arthritic Foxp3-GFP-Cre × ROSA26-YFP mice that were performed 2 weeks after secondary immunization. ...
Figure 2.Localization, marker gene expression and DNA methylation status of exFoxp3 T cells in arthritic mice. Results are shown from fate mapping analyses of arthritic Foxp3-GFP-Cre × ROSA26-YFP mice that were performed 2 weeks after se...
Figure 2.Localization, marker gene expression and DNA methylation status of exFoxp3 T cells in arthritic mice. Results are shown from fate mapping analyses of arthritic Foxp3-GFP-Cre × ROSA26-YFP mice that were performed 2 weeks after secondary immunization. ...
(overlap) for CDR3α regions of the TCRs expressed by the mLN CD4+Tn, Tan, and Treg cells from TCRminiFoxp3GFPmice.dRelative diversity index quantified using the effective number of species (ENS) and presented in the form of diversity profiles43. Three individual mice were sequenced (23–...
1c, we detected substantial numbers of GFP-Foxp3-MSC (approximately 10–20 cells per section) liver graft of the recipients on POD7 after intraportal injection of allogeneic GFP-Foxp3-MSC. These finding suggests that Foxp3-MSC successful locates in the liver allograft....