Treg,Forkhead box P3 (FOXP3),Post-translational modification,Autoimmune,CancerForkhead box P3(FOXP3) is a ''master regulator" of regulatory T cells(Tregs), which are a subset of T cells that can suppress the antigen-specific immune reaction and that play important roles in host tolerance and...
Foxp3 is also expressed by tumor cells. It has been used recently as a biomarker and a prognostic factor for malignant human tumors [7]. Immunohistological staining of endogenous Foxp3 protein can be viewed (in both frozen and paraffin sections) in multipl...
Before considering the functional Treg characteristics as a prognostic criterion for MDS, one must take into account that the main regulator of Treg differentiation and function is the FOXP3 transcription factor [10]. Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of...
Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. Objectives;Recent data debate the suitability of Helios, an Ikaros family member, as a marker for thymic-derived regulatory T cells (Treg). Nevertheless, F... T Alexander,A Sattler,L Templin,... - 《Anna...
Foxp3在小鼠特异性表达于CD4+CD25+调节性 T细胞(regulatory T cells, Treg细胞)而不表达于CD8+T细胞,研究发现,Foxp3作为Treg细胞发育的一个关键转录因子,它的表达及功能与Treg细胞密切相关[4],可以更好地在分子水平上了解Treg细胞。 本实验室已经构建小鼠Foxp3/AAV表达载体[5],在此基础上我们构建原核表达载体...
Regulatory T (Treg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumour immunity1. Conversely, Treg instability, characterized by loss of the master transcription factor Foxp3 and acquisiti
FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in ...
Blimp-1 is a transcriptional repressor and master regulator of terminal B cell differentiation 36, 37, which also has important functions in T cells including Treg cells 7, 38, 39, 40, 41. Our recent research has shown that Blimp-1 expression defines eTreg cells as a distinct population of...
As recent reports have suggested a role for TGF-β in the generation and expansion of Tregs (17, 18, 19, 20), we hypothesized that TGF-β could induce de novo Foxp3 expression in CD4 + CD25 - precursor cells, which have not yet committed to the Foxp3 program. We confirmed this ...
Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT...