Nude severe combined immunodeficiency is a rare inherited disease caused by autosomal recessive loss-of-function mutations in FOXN1. This gene encodes a transcription factor essential for the development of the thymus, the primary lymphoid organ that supports T-cell development and selection. To date...
[2]Adriani M,Martinez-Mir A,Fusco F,et al. Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population[J]. Ann Hum Genet,2004,68:265-...
encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been ...
Gene ID:8456FOXN1 UniProt:O15353FOXN1 研究领域 免疫学 免疫学 适应性免疫学 GTX89637 IHC-P Image IHC-P analysis of human thymus Medulla using GTX89637 FOXN1 antibody, C-term. Antigen retrieval : citrate buffer pH 6 Dilution : 20μg/ml ...
Gene Summary Gene SymbolFoxn1 Synonyms nu, Whn, nude, Fkh19, Hfh11, HFH-11, D11Bhm185e NCBI ID 15218 MGI ID 102949 Ensembl ID ENSMUSG00000002057 Pubmed Foxn1 Human Ortholog Associated Diseases by GWAS 免疫缺陷、先天性脱发 Model Description 通过敲除Foxn1基因exon 5,建立Foxn1基因敲除小鼠模...
Gene Name: FOXN1 RONU WHN Protein Name: Forkhead box protein N1 (Winged-helix transcription factor nude) Human Gene Id: 8456 Swiss-Prot: O15353 Formulation: Liquid in PBS containing 50% glycerol, and 002% sodium azide Source: Rabbit Purification: The antibody was affinity-purified from rabbit...
Entrez Gene:8456 Swiss Prot:O15353 Source:KLH conjugated synthetic peptide derived from human FOXN1:321-420/648 Purification:affinity purified by Protein A Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid re...
裸鼠的胸腺芽基 regulatetheexpressionofFoxN1,the genedefectivein nude mice 不表达 CCL25和 CXCL12趋化因子,因此造血干细胞不能有 [J].NatImmunol,2002,3(11):1102—1108. 效地迁移至Foxnl缺失胸腺。Notch信号对于T细胞分化定 [9]OsadaM,JradineL,MisirR,eta1.DKK1mediatedinhibitionof Wntsignalinginpostnatal...
Neotenic phenomenon in gene expression in the skin of Foxn1-deficient (nude) mice-a projection for regenerative skinwound healing[J]. BMC Genomics, 2017, 18:56. doi: 10.1186/s12864-016-3401-z. [13]Gawronska-Kozak B, Grabowska A, Kur-Piotrowska A, et al. Foxn1 transcription factor ...
b5t-encoding gene in the mouse genome is encoded by a single exon located within the 14-kb region between b5-encoding and Cdh24-encoding genes in chromosome 14 (ref. 6) (Fig. 1a). Within this 14-kb region, we searched for the 11-bp Foxn1- binding consensus motif, a a/g n g A...