[2]Adriani M,Martinez-Mir A,Fusco F,et al. Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population[J]. Ann Hum Genet,2004,68:265-...
The FOXN1 leads to congenital alopecia and an alymphoid thymus with severe combined primary T-cell immuno- deficiency,7,44–46 resulting in death in early childhood from severe infections.44,47 Therefore, gene therapy with FOXN1 is one of options to be possibly selected to treat fetal FOXN1...
The FOXN1 gene mutation is a unique disorder that causes the nude severe combined immunodeficiency phenotype. In patients with severe combined immunodefici... O Corbali,HBG Karaaslan,S Aydemir,... - 《Journal of Pediatric Hematology/oncology》 被引量: 0发表: 2023年 Comprehensive phenotypic analysi...
FOXN1 is the master regulatory gene of thymic epithelium development. FOXN1 deficiency leads to thymic aplasia, alopecia, and nail dystrophy, accounting for the nude/severe combined immunodeficiency (nu/SCID) phenotype in humans and mice. We identified several newborns with low levels of T cell ...
GENE therapyThis study aimed to investigate whether the genetic variants of genes are functionally associated with OA in Chinese population. With the identification of more susceptible loci, the combined effect of these markers may be helpful for the surveillance of ...
143. Use of ciliated cell specific promoter FoxJ1 in gene transfer vectors for the airway epitheliumRNA transfectiondendritic cellcytotoxic T lymphocytesadoptive therapyvaccine therapymt is a cross-disciplinary biomedical journal devoted to publishing the most exciting advances in pharmacology and ...