Here we demonstrate that glycogen synthase kinase-3beta (GSK-3beta) is an effective kinase for protein tau in cerebral neurons in vivo in adult GSK-3beta and GSK-3beta x human tau40 transgenic mice. Phosphorylated protein tau migrates slower during electrophoretic separation and is revealed by...
Castilla J, Gutierrez-Adan A, Brun A, Pintado B, Salguero FJ, Parra B, Segundo FD, Ramirez MA, Rabano A, Cano MJ, Torres JM: Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an ...
Interpretation of data from gene targeting studies can be confounded by the inherent traits of the background inbred strains used in the generation of transgenic and null mutant mice. We have therefore compared the behaviour and response to CNS injury of four inbred strains commonly used in molecul...
Follicular lymphoma (FL) is the second most common subtype of adult B-cell NHL in Western countries and is characterized by the chromosome translocation t (14;18). This abnormality promotes tumor cell survival through overexpression of the anti-apoptotic protein Bcl-2. Of interest, mice overexpres...
However, in inhalation studies with very young or very small mice (e.g., transgenic strains), it can be difficult to cut the nose in four levels. For those exceptions, the following three level-procedure is recommended: 应该相似整理老鼠作为鼠。 然而,在吸入研究与非常年轻人或非常小老鼠(即, ...
important in both store-operated and receptor-operated Ca2+entry54.Trpc3overexpression induces myocardial hypertrophy via calcineurin/NFAT in transgenic mice65, while left ventricular pressure overload by transverse aortic constriction or angiotensin-II infusion upregulated TRPC non-selective cation current ...
Publication » Dystriphic neurites in plaque-like Aβdeposits in mice double transgenic for the APP 670 671 mutation and the human four-repeat tau protein.doi:10.1016/S0197-4580(00)82206-XMarkus TolnayKarl-Heinz WiederholdAlphonse Probst
In mice transgenic for the LACK antigen and with a genetic background susceptible to the infection, the induction of tolerance to this antigen protects against the infection by Leishmania major. The anti-Leishmania antibodies can destroy the promastigotes in vitro in the presence of complement, ...
Generation of phospho-specific ERα antibodies provided the tools to validate phosphorylation sites and to begin to assess the functional significance of these specific sites. Accordingly, these phospho-specific antibodies were used to detect phosphorylation of each residue by Western blot/...
Generation of Cells Synthesizing Four Major Immunoglobulin Classes Cultured cells from mouse thoracic duct, spleen, lymph node, Peyer's patches, and bone marrow gave rise to cells containing large amounts of cytoplasmic Ig... JF Kearney,AR Lawton - 《Journal of Immunology》 被引量: 563发表: ...