Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non- transmissible, neurodegenerative disease and an expedited course of BSE infection. FEBS Lett 579, 6237-6246.Klimaszewska, K.; Bernier-Cardou, M.; Lachance, D.; Rutledge, R. G....
14,15,16,17] to discriminate genotoxic hepatocarcinogens from non-genotoxic hepatocarcinogens in mice [13,14,16] and in rats [15] for use in an in vivo short-term toxicogenomics screening test for genotoxic carcinogens. We proposed 12 genotoxic marker genes (...
Short-term in vivo testing to discriminate genotoxic carcinogens from non-genotoxic carcinogens and non-carcinogens using next-generation RNA sequencing, DNA microarray, and qPCR Article Open access 09 February 2023 A novel support vector machine-based 1-day, single-dose prediction model of genotoxi...
Dystriphic neurites in plaque-like Abetadeposits in mice double transgenic for the APP 670671 mutation and the human four-repeat tau proteindoi:10.1016/S0197-4580(00)82206-XMarkusTolnayandKarl-HeinzWiederholdandAlphonseProbstandKurtSDOSNeurobiology of Aging...
important in both store-operated and receptor-operated Ca2+entry54.Trpc3overexpression induces myocardial hypertrophy via calcineurin/NFAT in transgenic mice65, while left ventricular pressure overload by transverse aortic constriction or angiotensin-II infusion upregulated TRPC non-selective cation current ...
Generation of FHL and cMyBP-C Constructs—β-Galactosidase, FHL1, FHL2, and FHL3 cDNA were cloned previously into the XbaI site of the pCGN vector (21, 42). The full-length cMyBP-C cDNA was cloned into the MluI site of the pEFBOS-FLAG vector to generate a fusion protein containing an...
Generation of phospho-specific ERα antibodies provided the tools to validate phosphorylation sites and to begin to assess the functional significance of these specific sites. Accordingly, these phospho-specific antibodies were used to detect phosphorylation of each residue by Western blot/...
Therefore, in this study, 12-month-old male APP/PS1 double transgenic mice were given a regular treadmill running intervention for four months, and the effects of exercise on cognitive function and the number of spinophilin-immunoreactive puncta in the different regions of the hippocampus in AD ...
Aguzzi. 2002. Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau. J. Neurosci. 22:7471-7477.Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau - Ku虉nzi, Glatzel, et...
The generation of antibodies that would be suitable for use in accord with the present invention is discussed below. E. Synthetic Peptides The present invention also describes smaller FJX1-related peptides for use in various embodiments of the present invention. Because of their relatively small ...