These conditions may be causing folate deficiency, require additional medications or a higher dose of folic acid, or further laboratory investigation. For example: Folic acid in dosages above 0.4mg daily may hide laboratory changes caused by pernicious anemia without halting the progression of neurolog...
For DNA synthesis. Vit B12is necessary for synthesis of the active tetrahydrofolate form (FH4)Drugs e.g. methotrexate in cancer chemotherapy also anti-convulsants e.g. phenytoin. Note: 1. Since the marrow and blood changes infolic acidand vitamin B12deficiency are similar, the differential ...
There is a reluctance to switch to supplements containing 2.8 mg of folic acid because of a lack of evidence that this dose would prevent NTDs. Our aim was to investigate the effect of two doses of folic acid, compared with placebo, on red blood cell (RBC) folate, a biomarker of NTD ...
A large study found that folic acid supplementation did not reduce colorectal adenoma risk; ev- idence for an increased risk of adenomas with supplementation was equivocal.2 Animal studies suggest that folic acid may have dual modulatory effects on carcinogenesis, depending on dose and timing of ...
The effects of folate deficiency and folic acid (FA) supplementation on folate absorption and metabolism have not been well established . We investigated the effects of folate deficiency and FA supplementation on gene expression of folate receptors/transporters and metabolic enzymes in a mouse model. ...
Folic acid (folate,59-30-3) is a kind of B-vitamin which is mainly present in the liver and kidney. It has various kinds of pharmacological and physiological effects. It is involved in amino acid metabolism, purine and pyrimidine synthesis, and is also essential for hematopoiesis and red bl...
Folate deficiency You are more likely to be deficient in folic acid if you are pregnant, breastfeeding or experience excessive loss of this vitamin. This might occur due to alcoholism; using certain medications, such as diuretics; having celiac disease that goes untreated; or having Crohn’s di...
Uses for Folic Acid Anemia Treatment of megaloblastic anemias due to folic acid deficiency as may be seen in tropical or nontropical sprue, nutritional anemias, and in anemias of pregnancy, infancy, and childhood. Dietary Requirements Adequate intake of folate needed to prevent megaloblastic changes...
Folic acid is primarily used in the pharmaceutical industry. Its main purpose is as a vitamin supplement, particularly in the treatment of folate deficiency and certain types of anemia. Folic acid plays a crucial role in DNA synthesis and cell division, making it essential for proper growth and...
Comparison Of Folic Acid With Natural Dietary Folates Is There Evidence That Elevated Blood Folate Concentrations May Cause Harm? Does Folate Play A Dual Role In Cancer? Will Increasing The Concentration Of Blood Folates Modify The Effects Of Antifolate Drugs? Does Folic Acid Have Any Genetic Or...