The folic acid antagonists enjoy a unique place in cancer chemotherapy (Holland, 1961). Aminopterin was the first designed antimetabolite which provided significant regression of a neoplasm, acute lymphocytic leukemia in children (Farber et al., 1948). Nearly ten years ago, in October 1955, ...
the action of each agent is potentiated resulting in enhanced activity against bacteria. Potentiated sulfonamides are selectively toxic for bacteria because animals can absorb preformed folic acid from their feed.Figure 1provides a brief schematic summary of the different classes of antibacterial drugs and...
In metabolism of homocysteine,folic acid is an important cofactor.That decreased enzyme activity is the main agent of causing hyperhomocysteine.Hyperhomocysteine is one of the risk factors of cardiovascular and cerebrovascular disease,lower homocysteine can effectivelly decrease the risk of cardiovascular ...
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Mechanism of Action Folic acid acts as a coenzyme in various metabolic reactions, particularly in the synthesis of nucleotides and amino acids. It is converted into its active form, tetrahydrofolate, which plays a vital role in the transfer of one-carbon units during these biochemical processes. ...
1981 . Studies of the mechanism of action of asulam in plants. II. Effect of asulam on the biosynthesis of folic acid. Pestic. Sci 12: 330 – 338 . ,Veerasekaran et al., " Studies of the mechanism of action of asulam in plants. Part II: Effect of asulam on the biosynthesis of ...
Folic acid antagonists Previously, folic acid antagonists, which are known to be highly embryolethal, were used in clinical trials as abortifacients (agents causing abortion). Although three-fourths of the pregnancies were terminated, almost one-fourth of the embryos that survived to term were ...
Mechanism of action of folic acid The mechanism is still being investigated but several positive facts are emerging. Firstly, it seems unlikely that there is a primary folate deficiency. Kirk et aI have shown that mothers carrying foetuses with neural tube defects have a lower Bl2/folate during ...
mechanism of FA action are urgently needed. Human induced pluripotent stem cell (iPSC) technology could provide an attractive model to recapitulate the disease with its specific mechanisms and address early events in NTD manifestation. During the early neural differentiation, pluripotent stem cells (PS...
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