It would therefore seem that the depression of folic acid levels in patients on anticonvulsants depends on individual factors and perhaps duration of treatment rather than being a toxic, dose-dependent response.doi:10.1007/BF00594091Amos D. Korczyn...
Folate, a water-soluble B vitamin, and its synthetic form folic acid (FA) used in fortification and supplements, are critical to human health due to their role in one-carbon transfer reactions required for biological methylation and nucleotide biosynthesis. As such, folate deficiency has been link...
the vitamin B complex that function in the metabolism of nucleic acids and amino acids and are found in leafy greens, fresh fruits, legumes, liver, and eggs, or are produced in the body by metabolism of folic acid. Folate deficiency during pregnancy can lead to neural tube defects in ...
Folate deficiencyfirst becomes visible in high-turnover cells, such as erythrocytes, resulting in megaloblastic anemia because of a deficit in DNA, necessary for normal cell division[2]. Other consequences are the induction of hyper-homocysteinemia, a risk factor for cardiovascular disease[66], mis...
Folate Deficiency and Nutritional Disorders - Learn about from the Merck Manuals - Medical Professional Version.
Results:When compared to dams fed a folate-replete diet, those dams on a folate-depleted diet developed reduced red cell folates and hyperhomocysteinemia and an inverse dose-dependent upregulation of FR and hnRNP-E1 on GD17 without alterations in cell number in the majority of tissues. However...
Neurological improvement following intravenous high-dose folinic acid for cerebral folate transporter deficiency caused by FOLR-1 mutation •The main clinical manifestations ofFOLR-1mutations are regression in the second year of life, ataxia, and myoclonic epilepsy.•Cerebral folate transp... F Del...
Dose-Response Association of Maternal Levels of Folate, Vitamin B12, and Homocysteine With Congenital Heart Disease (CHD) Risk in Offspring. Credit:JAMA Network Open(2024). DOI: 10.1001/jamanetworkopen.2024.38747 Pregnant women with either low or excessively high levels of folate in their blood may...
Ongoing intervention studies can strengthen evidence for causality by excluding such confounding, but the optimal dose, duration, and stage of carcinogenesis and the appropriate (genetically predisposed) study group for folate chemoprevention are not yet defined. 展开 ...
However, if you are taking methotrexate for arthritis, folate supplementation will help prevent some of these same side effects. Talk to your physician about taking the dose of folate that is best for you. For general health purposes, 400 mcg per day of folate is plenty. Vitamin B12 should ...