KEGG enrichment analysis of differentially expressed genes and proteins showed that several pathways in addition to folate biosynthesis were likely indirectly involved in folate metabolism and content (e.g., glycine, serine, and threonine metabolism; purine metabolism; cysteine and methionine metabolism; ...
KEGG pathway indicating the extent of Folate Biosynthesis in Liberibacter species.Jennie, R. FagenMichael, T. LeonardConnor, M. McCulloughJanaka, N. EdirisingheChristopher, S. HenryMichael J., DavisEric, W. Triplett
2c), revealed thfT is inserted between murF and ddlA, two genes that comprise part of the core GAS genome and encode enzymes involved in peptidoglycan biosynthesis. The 5 bp duplication in TB08-2-14 is in the intergenic region between thfT and the divergently transcribed gene ddlA. As ...
bypasses the inhibitory activity of SMX on the folate biosynthesis pathway (Fig.4b). If ThfT allows GAS to bypass the folate synthesis pathway altogether in the presence of extracellular THF, then strains that harborthfTshould have complete resistance to SMX in the presence of extracellular THF. ...
Several KEGG terms were shared by all genotypes, including d-glutamine and d-glutamate metabolism, aminoacyl-tRNA biosynthesis, valine, leucine, and isoleucine biosynthesis, and purine metabolism, reflecting general regulation of amino acid and nucleotide metabolism in common. A caveat of enrichment ...
and the folate biosynthesis function of the gut (Figure 4A). To date, the ability of gut Bacteroides spp. to produce folate has not been defined. First, we analyzed genes responsible for the synthesis of microbial folate in the genomes of B. xylanisolvens, B. thetaiotaomicron, B. dorei, ...
Because a number of the KEGG pathways are extremely general, we removed the four most inclusive pathways in consideration of “shared pathway” status: “Metabolic Pathways,”“Biosynthesis of secondary metabolites,”“Microbial metabolism in diverse environmennts,” and “Biosynthesis of antibiotics.”...
4. Biosynthesis of Folate Both prokaryotic and eukaryotic cells require reduced folate cofactors as acceptor/donor of one-carbon units in a variety of biosynthetic processes, including the formation of methionine, purines, and thymine, and in some degradative reactions. While the cellular requirement ...