These genes encode enzymes that potentially function in folate biosynthesis. Functional validation of one of these genes,ZmADCL2, using an EMS mutant (Mut9264) showed that a 4-base insertion in an exon increased
and the pteridine branches of the folate pathway were recently reported (Díaz de la Garza et al., 2007; Storozhenko et al., 2007), and the strategy is well in place to be implemented in other crops such as potato tubers which contain all the genes necessary for folate biosynthesis. Ot...
Reprints and permissions About this article Cite this article Blancquaert, D., Van Daele, J., Storozhenko, S. et al. Rice folate enhancement through metabolic engineering has an impact on rice seed metabolism, but does not affect the expression of the endogenous folate biosynthesis genes. Pla...
yeast and fungi synthesize folatesde novoand therefore constitute a very important dietary source of folates for animals. All the major steps of folate biosynthesis and metabolism have been identified but only few have been genetically characterized in a handful of model plant species. The possible ...
Folates are required for the normal growth and proliferation of all cells and when they are not available cells ultimately die. A better understanding of the biosynthesis of folates and the consequences of disturbing folate biosynthesis in microorganisms will contribute to our understanding of this ...
Folates enable the activation and transfer of one-carbon units for the biosynthesis of purines, thymidine and methionine1,2,3. Antifolates are important immunosuppressive4 and anticancer agents5. In proliferating lymphocytes6 and human cancers7,8, mitochondrial folate enzymes are particularly strongly ...
and redox balance. Folate over-intake may lead to the accumulation of unmetabolized folic acid that has been associated with several chronic inflammatory conditions, including cancer [7]. Folate can modulate the expression of genes encoding for pro-inflammatory and pro-fibrotic cytokines, and, eventu...
Amongst the antimalarial drugs currently in clinical use, the antifolates have the best defined molecular targets, namely the enzymes dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS), which function in the folate metabolic pathway. The products of this pathway, reduced folate ...
6.Association between Polymorphisms of Folate Metabolism-Related Genes and Susceptibility to Nasopharyngeal Carcinoma;叶酸代谢酶基因多态性与鼻咽癌的遗传易感性研究 7.The role of folate metabolism related enzymes gene polymorphisms on recurrent early spontaneous abortion叶酸代谢酶基因多态性与反复自然性流产易感性...
Instead, maternal low folate status appears to interact with fetal genes and other dietary factors affecting single-C metabolism. In animal models, this involves epigenetic marks on promoters essential for neurogenesis142 and normal activity of SHMT.143 In humans, this includes MTHFR 677C > T ...