Folate biosynthesis remains a key target for antimicrobial therapy. Folate is an essential vitamin (vitamin B9) that is required for many one-carbon transfer reactions and is a critical precursor for the biosynthesis of purines, pyrimidines, and amino acids. Unlike higher eukaryotes that scavenge ...
网络叶酸合成 网络释义 1. 叶酸合成 ...hesion molecules (CAMs))、叶酸合成(Folate biosynthesis)、不饱和脂肪酸合成(Biosynthesis of unsaturated fatty acids)等,说… cdmd.cnki.com.cn|基于 1 个网页
Folate biosynthesis has been well delineated in recent years, enabling metabolic engineering of the pathway. Successes in enhancing folate production in tomato fruit and rice grain by overexpressing the first enzyme of both the para-aminobenzoic acid and the pteridine branches of the folate pathway we...
The folate biosynthesis pathway has been a target for antibiotic therapy for over 80 years6. The end products of this pathway, 7,8-dihydrofolate (DHF) and 5,6,7,8-tetrahydrofolate (THF), are key intermediates in the folate cycle that is required for production of deoxythymidine monophosphate...
yeast and fungi synthesize folatesde novoand therefore constitute a very important dietary source of folates for animals. All the major steps of folate biosynthesis and metabolism have been identified but only few have been genetically characterized in a handful of model plant species. The possible ...
RNA-seq and qRT-PCR analysis revealed that BB influenced the expression levels of multiple genes (Ccnd2, Reln, Pgf, Mylk3, Ppplr12c, Thbsl), by promoting folate biosynthesis for hearing protection. Conclusion: Our findings suggest that BB protects against cisplatin-induced hearing...
bypasses the inhibitory activity of SMX on the folate biosynthesis pathway (Fig.4b). If ThfT allows GAS to bypass the folate synthesis pathway altogether in the presence of extracellular THF, then strains that harborthfTshould have complete resistance to SMX in the presence of extracellular THF. ...
Inhibition of folate biosynthesis and function as a basis for chemotherapy. Adv. Enzymol. Relat. Areas Mol. Biol. 27:417-468.Hitchings, G. H., and J. J. Burchall. 1965. Inhibition of folate biosynthesis and function as a basis for chemo- therapy. Adv. Enzymol. 27:417-468....
Folate Biosynthesis Pseudogenes, folP and folK, and an O-Sialoglycoprotein Endopeptidase Gene Homolog in the Phytoplasma Genome Studies the purine biosynthesis in the archaea domain without folates or modified folates. Pathway for steps in biosynthesis; Techniques used for the incor... Davis,R.,...
The deficiencies in folate biosynthesis were due to an aroD mutation, or treatment of E. coli with sulfa drugs, which are mimics of the folate precursor para-aminobenzoic acid. This study suggests that pharmacological manipulation of the gut microbiome folate status may be a viable approach to...