E. (2008) An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites. Mol. Microbiol. 67, 609-618.Dittrich S, Mitchell SL, Blagborough AM, Wang Q, Wang P, et al. An atypical orthologue of 6-pyruvoyl...
flaccidum the entire folate biosynthesis pathway (except for the ADCS activity) could take place in the cytosol. Analysis of subcellular compartmentalization of genes involved in interconversion of folate species suggests that the sources of one-carbon units in plant cells are specific for different ...
tetrahydrofolate biosynthesis, in plantsplant THF biosynthetic pathwaycatabolism, salvage pathwayfolate deficiency diagnosisdoi:10.1002/9781118253649.ch6Stéphane RavanelLaboratoire de Physiologie Cellulaire Végétale, UMR5168 CNRSUMR1200 INRA – CEA︰niversité Joseph Fourier Grenoble I, Institut de Recherches ...
Summary of folate biosynthesis pathway in Plasmodia. Abbreviations not in main text: SHMT, serine hydroxymethyltransferase; Ser, serine; Gly, glycine; dUMP, deoxyuridine monophosphate; TS, thymidylate synthase; MTHFR, methylenetetrahydrofolate reductase; MS, methionine synthase; Hey, homocysteine; Met, ...
The tetrahydrofolate biosynthesis pathway. The enzymes that have not yet been cloned from plants are highlighted in black. The numbers of genes that encode, or putatively encode, each enzyme in Arabidopsis are shown in parentheses. DHFR, dihydrofolate reductase; DHFS, dihydrofolate synthetase; DHPS...
The folate biosynthesis pathway has been a target for antibiotic therapy for over 80 years6. The end products of this pathway, 7,8-dihydrofolate (DHF) and 5,6,7,8-tetrahydrofolate (THF), are key intermediates in the folate cycle that is required for production of deoxythymidine monophosphate...
A better understanding of the biosynthesis of folates and the consequences of disturbing folate biosynthesis in microorganisms will contribute to our understanding of this important biochemical pathway as well as assist us to devise appropriate drug that are not subject to jeopardize any event associated...
F. (1998). The folate branch of the methionine biosynthesis pathway in Streptomyces lividans: disruption of the 5,10-methylenetetrahydrofolate reductase gene leads to methionine auxotrophy. J Bacteriol 180, 1586-1591.Blanco J, Coque JJR, Martin JF (1998) The Folate Branch of the Methionine ...
(2007) Characterization of the Role of para-Aminobenzoic Acid Biosynthesis in Folate Production byLactococcus lactis. Appl Environ Microbiol73, 2673-2681) was also digested with XbaI and KpnI. Both digested pieces of DNA were mixed in a 1:5 ratio (plasmid:insert), and were ligated by T4 DNA...
(2007) Characterization of the Role of para-Aminobenzoic Acid Biosynthesis in Folate Production byLactococcus lactis. Appl Environ Microbiol73, 2673-2681) was also digested with XbaI and KpnI. Both digested pieces of DNA were mixed in a 1:5 ratio (plasmid:insert), and were ligated by T4 DNA...