Epileptic seizures are caused by abnormal electrical activity of brain cells, frequently accompanied by a short-lived loss of control or awareness. Epileptic seizures differ depending on their origin in the brain. They can be categorized as either focal or generalized in onset. The identification of...
Most reports of the ketogenic diet have focused on its efficacy for generalized seizures. Few data are available regarding its effect on focal seizures. We retrospectively studied patients (mean = 7.5 years of age) with medically intractable epilepsy treated by the ketogenic diet. The predominant se...
Generalized epileptic discharges leading into focal onset seizure: GOFE seizures as the initial diagnosis of epilepsy doi:10.1007/s00415-024-12841-zSpringer Berlin HeidelbergJournal of NeurologyDavide Gusmeo Curtihttps://ror.org/039zxt351grid.18887.3e0000000417581884Neurology UnitIRCCS San Raffaele ...
Development of a New Pharmacological Seizure Model: Effects of Anticonvulsants on Cortical‐and Amygdala‐Kindled Seizures in the Rat The potency of eight standard anticonvulsants was tested in dose-response studies on kindled rats. Animals with either amygdala- or cortical-generalized seizures were ...
fronto-parietal cortices have typically shown increased simultaneous neuronal activity during generalized seizures75,76. Moreover, prior neuroimaging work in IGE patients that analyzed cortical morphology has shown widespread cortical structural network compromise6,77, with midline frontal and paracentral region...
Focal to bilateral tonic–clonic seizuresHypoxemiaEpilepsy monitoring unitSudden unexpected death in epilepsyTo investigate potentially high-risk cardiac arrhythmias (PHAs) following focal to bilateral tonic-clonic seizures (FBTCSs) and generalized tonic-clonic seizures (GTCSs) and to study the association...
Objective To assess the effectiveness and tolerability of perampanel (PER) monotherapy in routine clinical practice for the treatment of focal onset and generalized tonic‐clonic seizures (GTCS). Methods This multicenter, retrospective, observational study was conducted in patients aged ≥12 years treated...
Key exclusion criteria were uncountable seizures (i.e., because of clustering), which would preclude the explorative evaluation of therapeutic benefit, a history of primary generalized seizures, or status epilepticus within 6 months (patients ≥2 years of age) or 1 month (patients <2 years of ...
dysplasia subtypes Samantha L Simpson and Richard A Prayson Department of Anatomic Pathology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, OH, USA Focal cortical dysplasias are a well-recognized cause of medically intractable seizures. The...
Primary generalized tonic–clonic seizures were reduced by 76.5% (8 mg) vs 38.4% (placebo) in a recent controlled trial. Overall, perampanel is well tolerated and the main adverse events are dizziness, somnolence and fatigue. There are also anecdotal reports on use in progressive myoclonic ...