Nano-organocatalystIron oxide nanoparticlesMicrowaveBoc, Fmoc deprotectionWe report the elaboration of new L-Proline functionalized superparamagnetic iron oxide nanoparticles that can act as a new enantioselective organocatalyst. Boc-L-Proline and Fmoc-L-Proline are grafted using two different ...
solvent freesustainable chemistryMaking a Fmoc-ery of it: We report an efficient, quick, and sustainable method for the protection of amines with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This solvent-free approach results in good-to-excellent isolated yields of the desired products within only ...
We find that orthogonal allyloxycarbonyl (Alloc) protection of a single Dbz amine eliminates these side products. We introduce a protected Fmoc-Dbz(Alloc) base resin that may be directly used for synthesis with most C-terminal amino acids. Following synthesis, quantitative removal of the Alloc ...
Fmoc-@b-Ala-OHLossen rearrangementPeptide synthesisFmoc-OSu has been widely used for Fmoc protection of amino groups, especially amino acids, in solid phase peptide synthesis. However, it has been recognized that Fmoc-βAla-OH is formed as a by-product via the Lossen rearrangement during the ...
An efficient and expeditious Fmoc protection of amines 690 and amino acids in aqueous media. Green Chem. 2011;13:3355-9.Gawande, M. B. & Branco, P. S. An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media. Green Chem. 13, 3355-3359 (2011)....
S. An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media. Green Chem. 13, 3355-3359 (2011).Manoj B. Gawande,Paula S. Branco.An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media.Green Chemistry. 2011...
A Greener, Efficient and Catalyst-Free Ultrasonic-Assisted Protocol for the N-Fmoc Protection of Aminesdoi:10.5935/0103-5053.20150286Rachida MansouriZineb AoufSalah LakroutMalika BerredjemNour-Eddine AoufBrazilian Chemical Society
Carreño et al, " Nsc and Fmoc Nα-amino Protection for Solid-Phase Peptide Synthesis: A Parallel Study, " Peptide Res., vol. 56, pp. 63-69 (2000).Carreno C, Mendez ME, Kim YD, Kim HJ, Kates SA, Andreu D, Albericio F (2000) Nsc and Fmoc Nα-amino protection for solid-...
PeptideFluorous mixture synthesisf-Fmoc reagentNatural productStereoisomersThe syntheses of fluorous-Fmoc reagents and their application to peptide synthesis are described. Fluorous-Fmoc reagents bearing C3F7, C4F9, and C6F13chains were prepared at a multigram scale and......
The majority of peptides produced on solid phase are prepared using the fluorenylmethoxycarbonyl (Fmoc)-fert-butyl (YBu) orthogonal protection strategy . However, the synthesis of cyclic and branched peptides may require oil protecting groups orthogonal to Fmoc and tBu.Albert Isidro-Llobet...