Orthogonal protection of amino acid side chains in solid phase peptide synthesis allows for selective deprotection of side chains and the formation of cycl... KR Wilson,S Sedberry,R Pescatore,... - 《Journal of Peptide Science》 被引量: 1发表: 2016年 ...
It is commonly used as a building block in solid-phase peptide synthesis, providing protection to the cysteine residue during the synthesis process. Fmoc-S-acetamidomethyl-L-cysteine offers a reliable and efficient method for the incorporation of cysteine residues into peptides, enabling the study ...
Conditions: Store in a cool and dry place. View all 4. Safety and Handling4.1 Specification Fmoc-cys(mmt)-OH , with CAS number of 177582-21-7, can be called N-alpha-(9-fluorenylmethoxycarbonyl)-s-p-methoxytrityl-l-cysteine ; N-alpha-(9-fluorenylmethyloxycarbonyl)-s-p-methoxytrityl-...
Selective Removal of Fluorenylmethoxycarbonyl (FMOC) Groups Under Mild Conditionsprotection, deprotectionN-Fluorenylmethoxycarbonyl groups may be removed by potassium fluoride/18-crown-6 in the presence of methyl, ethyl, tert-butyl, benzyl, and p-methoxybenzyl esters....
Conditions for safe storage, including any incompatibilities Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials. SECTION 8: Exposure controls/personal protection Control parameters Occupational Exposure limit values ...
摘要: Describes the development of Fmoc-O-[bis-dimethylamino)phosphono]tyrosine for the preparation of peptides containing phosphotyrosine or one of its analogue. Modeling of the chemistry behind its protection strategy upon hydrolytic liability of the P-N bond under acidic conditions....
conditions of coupled action and deprotection.It can be removed by dilute acetic acid at tallish temperature,or by TFA at room temperature.So we chose Trt as the side-chain protecting group.With the methods of central composite design and orthogonal design,the final optimized conditions were ...
Conditions for safe storage, including any incompatibilities Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials. SECTION 8: Exposure controls/personal protection ...
compositedesignandorthogonaldesignthefinaloptimi zedconditionswereobtainedandtheyieldsofthetwostepsreachedabove80respectively.Thepu ritywasabove95.Keywords:histidineprotectiontritylTrt92fluorenylmethylFmoc收稿日 期:2008202228修回日期:2008205216基金项目:上海市科委科研计...
the Fmoc group is removed typically with piperidine, which in turn scavenges the liberated dibenzofulvene to form a fulvene-piperidine adduct. Standard conditions for removal include 30% piperidine-DMF for 10 min (11), 20% piperidine-DMF for 10 min (12, 13), 55% piperidine-DMF for 20 min ...