Making a Fmoc-ery of it: We report an efficient, quick, and sustainable method for the protection of amines with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This solvent-free approach results in good-to-excellent isolated yields of the desired products within only five minutes under microwave ...
FMOC-SUBEROL, with the chemical formula C29H27NO4 and CAS registry number 212783-75-0, is a compound known for its applications in organic synthesis and as a protecting group for amines. This compound, also referred to as 9-Fluorenylmethoxycarbonyl-suberol, is characterized by its fluorenyl...
FMOC-D-4-Fluorophe is mainly used in the field of chemical synthesis. Its purpose in this field involves its ability to act as a protecting group for amines during organic synthesis. The mechanism of action in chemical synthesis involves the temporary attachment of FMOC-D-4-Fluorophe to the...
agents to form stable adducts (1, 2). The stability of the Fmoc group to a variety of bases (6–10) is reported in Table 1. The Fmoc group is, in general, rapidly removed by primary (i.e., cyclohexylamine, ethanolamine) and some secondary (i.e., piperidine, piperazine) amines, ...
introduction chloroform-9-fluorenyl methyl ester (Fmoc-Cl) is a protective reagent for primary and secondary amines and is sensitive to bases. It is usually used for the synthesis of polypeptides or derivatization before amino and amino acid HPLC analysis and fluorescence detection. properties chlor...
Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION ? Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 157887-82-6: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear...
(1, 2). The stability of the Fmoc group to a variety of bases (6–10) is reported in Table 1. The Fmoc group is, in general, rapidly removed by primary (i.e., cyclohexylamine, ethanolamine) and some secondary (i.e., piperidine, piperazine) amines, and slowly removed by tertiary (...
Fmoc protection also serves as a crucial method in solid phase peptide synthesis because it could be removed by piperidine without disturbing the linker between the peptide and the resin. In addition, due to the fluorescent property of Fmoc group, it could react with certain UV-undetectable ...
The reaction proved to be chemoselective in presence of ambident nucleophiles.doi:10.1039/c1gc15868fManoj B. GawandePaula S. BrancoThe Royal Society of ChemistryCheminformGawande, M. B. & Branco, P. S. An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media. ...
S. An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media. Green Chem. 13, 3355-3359 (2011).Manoj B. Gawande,Paula S. Branco.An efficient and expeditious Fmoc protection of amines and amino acids in aqueous media.Green Chemistry. 2011...