Larsen B, Holm A (1994) Incomplete Fmoc deprotection in solid phase synthesis. Int J Pept Protein Res 43:1–9Larsen BD, Holm A. Incomplete Fmoc deprotection in solid-phase synthesis of peptides. Int J Pept Protein Res 1994;43:1-9....
et al. Fmoc deprotection using microwave-assisted continuous flow chemistry. Tetrahedron Lett. 2014, 55, 3315-3318. 3. Liu, K.; Gong, L.; Liu, R. et al. A facile and efficient Fmoc deprotection by using a microflow system. Tetrahedron Lett. 2014, 55, 3654-3657....
I did several test to check how the Fmoc deprotection take place...using piperidine (10 % and 20%) and also non-nucleophilic base DBU (2 %)...when I analyze by LC/MS I detect a new peak with the same intensity of the main product. It seems that is a side reaction...It has a...
Re: FMOC deprotection and work-up «Reply #10 on:March 16, 2022, 10:02:08 AM » From the silica column we obtained two small pools of products, neither one of which is our compound of interest. We cannot account for all of the mass that we put onto the column. Back to the dr...
去FMOC⽅法研究（转载）The electron withdrawing fluorene ring system of the 9-fluorenyl-methyloxycarbonyl (Fmoc) group renders the lone hydrogen on the β-carbon very acidic and, therefore, susceptible to removal by weak bases (1, 2). Following the abstraction of this acidic proton at the 9...
Deprotection peak heights as a function of host residue (-X-X-) and chain length in the SPPS of the known difficult peptide test sequence H-(Ala)n-X-X-(Ala)3-Val-polydimethylacrylamide (I). (a) General hydrophobic residues. (b) Effect of side-chain protection of cysteine. (c) ...
Fmoc(芴甲氧羰基):是一种保护基(protecting group),通常用于保护氨基官能团,以防止其在化学反应中发生非特异性的反应。这个官能团可以通过特定条件下的去保护反应(deprotection)来移除。 NH(氨基):表示分子中含有氨基官能团。 PEG12(十二聚乙二醇):是由十二个乙二醇单元组成的聚合物。PEG 被广泛应用于生物医学领域,用于...
Fmoc Amino Acids - Deprotection Procedure 1. Place the resin in a round bottom flask and add deprotection reagent (approximately 10 mL/gm of resin). 2. Shake the mixture at room temperature for 2 minutes. 3. Filter the resin. 4. Add deprotection reagent (approximately 10 mL/gm of resin)...
and has important reference value for the research on the synthesis and deprotection of polypeptides.%Fmoc是一种常用的氨基保护基,传统的脱除方法是通过加入二级胺与之作用来实现.针对方法中存在的成本较高、使用的过量二级胺不易回收以及污染环境等缺点,建立了利用新型无机碱纳米碳酸钾非均相脱除Fmoc保护基的新...
A rapid protocol based on Fmoc-chemistry for the solid phase peptide synthesis of vancomycin- and teicoplanin-type peptides is described. Epimerization of highly racemization-prone arlyglycine derivatives is suppressed through optimized Fmoc-deprotection and coupling conditions. Starting from easily accessibl...