Julia H Miwa,Laura A Margarida,Ann E Meyer.Improved acidolytic deprotection conditions for the Fmoc-based solid-phase synthesis of thioxo peptides. Tetrahedron Letters . 2001Miwa JH, Margarida LA, Meyer AE. Improved acidolytic deprotection conditions for the Fmoc-based solid-phase synthesis of ...
I did the deprotection with these mild conditions, 10% piperidine in DMF and 2 % DBU in DMF and I couldnt see my mass by LC/MS...so I guess that side reactions happen during the deprotection. I doubt you will see your mass in the MS as the azide group is labile under the conditio...
the Fmoc group is removed typically with piperidine, which in turn scavenges the liberated dibenzofulvene to form a fulvene-piperidine adduct. Standard conditions for removal include 30% piperidine-DMF for 10 min (11), 20% piperidine-DMF for 10 min (12, 13), 55% piperidine-DMF for 20 min ...
The Boc group on the side chain is stable under basic conditions and remains in place even through many Fmoc deprotection cycles. The Boc group of Fmoc-Lys(Boc)-OH is readily removed with trifluoroacetic acid (TFA) during cleavage of the peptide product from Wang resin or Rink amide resin....
The FMOC protecting group can be easily removed under mild conditions, allowing for the stepwise assembly of peptides. The mechanism of action in peptide synthesis involves the selective deprotection of amino acids using FMOC-D-BPA-OH. Storage Conditions: Store in a cool and dry place. View...
The dehydropentapeptide Nα-.Ac-Thr-Thr-δAba-Val-Thr-NH2, which would be formed in the case of β-elimination, was prepared independently and used as a control in HPLC analysis; however, this product was not formed under any of the deprotection conditions applied. Furthermore, a 23 amino...
A rapid protocol based on Fmoc-chemistry for the solid phase peptide synthesis of vancomycin- and teicoplanin-type peptides is described. Epimerization of highly racemization-prone arlyglycine derivatives is suppressed through optimized Fmoc-deprotection and coupling conditions. Starting from easily accessibl...
Selective Removal of Fluorenylmethoxycarbonyl (FMOC) Groups Under Mild Conditionsprotection, deprotectionN-Fluorenylmethoxycarbonyl groups may be removed by potassium fluoride/18-crown-6 in the presence of methyl, ethyl, tert-butyl, benzyl, and p-methoxybenzyl esters.doi:10.1080/00397919408013818...
Stepwise deprotection by morfoline (Fmoc-deprotection) followed by F⊖-mediated removal of Tmse results in a very effective peptide synthesis strategy, as exemplified by the preparation of i. a. Phg-MePhe-Thz. Similarly, combinations of N-Bc, O-Tmse peptide esters are also possible that ...
deprotection method of Fmoc group using a new inorganic base, namely,nano-potassium carbonate.Nano-potassium carbonate with average particle size 64 nm is prepared using wet grinding method.The deprotection of Fmoc-Phe-OBn is preformed as a Model reaction.The optimum conditions are that reaction ...