Mutations in the gene encoding profilaggrin (the filaggrin gene, FLG) were for quite some time suspected to influence the skin barrier. In 2006, the first two mutations were identified. Primarily due to the highly repetitive structure of the gene, genotyping had been difficult. Since then more...
#skin gene# filaggrin-皮肤屏障最早认识到filaggrin(丝聚蛋白,flg)与皮肤屏障关系是源于特应性皮炎(ad)-这一经典皮肤屏障功能障碍疾病的研究。flg变异有人群差异,北欧人群中携带者有10%,在亚洲人群中大概为3-6%,非洲人群中低于1%。flg如何影响皮肤屏障?作为角化包膜的组成成分和微丝聚集蛋白,它对于角质层结构和机械...
Key words Filaggrin gene; gene mutation; Filaggrin; atopic dermatitis; ichthyosis vulgaris1 前言Filaggrin基因, 简称FLG基因, 主要表达于皮肤颗粒层, 其翻译表达的聚角蛋白微丝蛋白前体(Pro-filaggrin)经降解为聚角蛋白微丝蛋白(Filaggrin), 后者位于皮肤角质层, 构成皮肤的保护屏障, 发挥防御功能。若FLG基因突变...
宿主 Mouse 克隆 Monoclonal 克隆编号 FLG01 同种型 IgG1 实验应用 WBICC/IFIHC-PIHC-Fr 种属反应 Human, Mouse 应用参考文献 7 提交文献 H Wanget al.J Funct Foods 2024; 122 : 106557 Oxyresveratrol from mulberry (Morus alba L.) ameliorates post-inflammatory hyperpigmentation in vitro by anti-melanog...
The relationship between the Filaggrin gene (FLG) rs2065955 polymorphism and susceptibility to Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) and EBV-negative gastric carcinoma (EBVnGC) was investigated in Shandong Province, China. We detected the FLG rs2065955 genotype and allele ...
Mutations in the filaggrin gene (FLG) result in an increased risk of atopic dermatitis through disruption of the skin keratin layer. This exploratory study investigated whether the preventive effect of maternal probiotics was evident in children with and without FLG mutations. D...
关键字: Filaggrin;FLG;Epidermal;filaggrin;Filaggrin precursor;Fillagrin;Profilaggrin;FILA_HUMAN;公司简介 上海沪震实业有限公司是一家集研发、生产和销售于一体的生命科学实验室产品生物科技企业。主营产品:试剂盒,ELISA试剂盒,抗体,重组蛋白,血清,胎牛血清,细胞,原代细胞 细胞培养试剂,常用生化试剂。 成立...
Given that approximately 50% of moderate-to-severe AD patients may be carriers of an FLG-null mutation, it has been speculated that FLG status may define a subtype of barrier-related AD. Since polymorphisms in the FLG gene lead to reduced amount of filaggrin and consequently to a decreased ...
Size 10ug, 50ug, 200ug Concentration n/a Applications n/a Other Names n/a Gene, Accession, CAS # SwissProt: P20930 Catalog # 154636 Price Order / More Info Filaggrin (FLG) Recombinant, Human from UNITED STATES BIOLOGICAL Product Specific References n/a 产品资料 ...
蛋白别名: Filaggrin-2; FLG-2; Ifapsoriasin; intermediate filament-associated and psoriasis susceptibility protein; Intermediate filament-associated and psoriasis-susceptibility protein 基因别名: FLG2; IFPS UniProt ID: (Human) Q5D862 Entrez Gene ID: (Human) 388698 功能 structural molecule activi...