Dear Editor, Atopic dermatitis, a common allergic and immunological skin disease, affects up to 20% of children and adults worldwide.1 Null variants of FLG encoding filaggrin were shown to be predisposing factors for AD.2 However, prevalence of FLG null variants in AD is low in some ...
Sheikh, AzizPrimary Care Respiratory JournalSimpson CR, Sheikh A. The filaggrin gene mutation, atopic dermatitis and asthma. Prim Care Resp J 2007;16:322-4↵ Simpson CR, Sheikh A. The filaggrin gene mutation, atopic dermatitis and asthma. Prim Care Respir J 2007 ; 16 : 322 -4....
The relationship between the Filaggrin gene (FLG) rs2065955 polymorphism and susceptibility to Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) and EBV-negative gastric carcinoma (EBVnGC) was investigated in Shandong Province, China. We detected the FLG rs2065955 genotype and allele ...
Referred to by Corrigendum: Loss-of-Function Mutations in the Filaggrin Gene Lead to Reduced Level of Natural Moisturizing Factor in the Stratum Corneum Journal of Investigative Dermatology, Volume 128, Issue 6, June 2008, Pages 1604 View PDFPrevious...
Corrigendum: Loss-of-Function Mutations in the Filaggrin Gene Lead to Reduced Level of Natural Moisturizing Factor in the Stratum Corneum A correction to the article "Loss-of-Function Mutations in the Filaggrin Gene Lead to Reduced Level of Natural Moisturizing Factor in the Stratum Corneum" ......
Loss-of-Function Mutations in the Filaggrin Gene Lead to Reduced Level of Natural Moisturizing Factor in the Stratum Corneum. J. Investig. Dermatol. 2008, 128, 2117–2119. [Google Scholar] [CrossRef] [Green Version] Kezic, S.; O’Regan, G.M.; Yau, N.; Sandilands, A.; Chen, H.;...
Genes.Genes seem to play a role. Kids who have a parent, brother, sister, or other family members with allergies or asthma are more likely to get eczema. Researchers have found that some people with the condition have a gene flaw that causes a lack of proteins called filaggrin and loricrin...
In addition to the lipid profile of the skin, the role of filaggrin and its breakdown product such as natural moisturizing factor are critical for maintaining skin barrier function. Null mutations in the FLG gene were first identified as a risk factor for AD in an Irish cohort, in which they...
(Robitaille et al.2010; Jonak et al.2011; O'Shaughnessy et al.2007). Co-localization studies revealed that in terminally differentiated keratinocytes, HSPB1 was a component of peripherally located multiprotein complexes comprising among others loricrin and filaggrin, key proteins engaged in the corn...
67. Steinert PM, Marekov LN: The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope. J Biol Chem 1995, 270:17702–17711. 68. Teigelkamp S, ...