Define filaggrin. filaggrin synonyms, filaggrin pronunciation, filaggrin translation, English dictionary definition of filaggrin. n a protein found in skin cells Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins
The discovery, in 2006, that loss-of-function mutations in the filaggrin (FLG) gene are the cause of ichthyosis vulgaris—the most common disorder of keratinization—and also a strong genetic risk factor for atopic eczema, marked a significant breakthrough in the understanding of eczema ...
Figure 1. Structure of the FLG gene and of the profilaggrin protein. These domains are also functional. The N-terminus domain is, in turn, formed by 2 subdomains: A and B. Subdomain A contains 2 calcium binding sites.25 It is the binding of calcium to this subdomain that produces a ...
WASp and related proteins act as important actin reorganization and polymerization activators67; it has been previously proposed that the mutation in the WAS gene could contribute to AD73. The exact role of α- and β-actins in the KHG scaffolds remains unclear because they could not be ...